Replikacioni protein A1

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Protein RPA1 PDB 1ewi.png
Available structures
PDBPretraga ortologa: PDBe RCSB
Spoljašnji IDOMIM: 179835 MGI: 1915525 HomoloGene: 2208 GeneCards: RPA1
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)n/aChr 11: 75.3 – 75.35 Mb
PubMed search[2][3]
View/Edit HumanView/Edit Mouse

Replikacioni protein A, 70 kDa DNK vezujuća podjedinica je protein koji je kod ljudi kodiran RPA1 genom.[4]

Interakcije[уреди | уреди извор]

Replikacioni protein A1 formira interakcije sa:

Reference[уреди | уреди извор]

  1. 1,0 1,1 1,2 GRCm38: Ensembl release 89: ENSMUSG00000000751 - Ensembl, May 2017
  2. ^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  3. ^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Umbricht CB, Erdile LF, Jabs EW, Kelly TJ (1993). „Cloning, overexpression, and genomic mapping of the 14-kDa subunit of human replication protein A”. J Biol Chem. 268 (9): 6131—8. PMID 8454588. 
  5. ^ Wong JM, Ionescu D, Ingles CJ (2003). „Interaction between BRCA2 and replication protein A is compromised by a cancer-predisposing mutation in BRCA2”. Oncogene. 22 (1): 28—33. PMID 12527904. doi:10.1038/sj.onc.1206071. 
  6. ^ Brosh RM, Li JL, Kenny MK, Karow JK, Cooper MP, Kureekattil RP, Hickson ID, Bohr VA (2000). „Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity”. J. Biol. Chem. 275 (31): 23500—8. PMID 10825162. doi:10.1074/jbc.M001557200. 
  7. ^ Opresko PL, von Kobbe C, Laine JP, Harrigan J, Hickson ID, Bohr VA (2002). „Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases”. J. Biol. Chem. 277 (43): 41110—9. PMID 12181313. doi:10.1074/jbc.M205396200. 
  8. ^ Moens PB, Kolas NK, Tarsounas M, Marcon E, Cohen PE, Spyropoulos B (2002). „The time course and chromosomal localization of recombination-related proteins at meiosis in the mouse are compatible with models that can resolve the early DNA-DNA interactions without reciprocal recombination”. J. Cell. Sci. 115 (Pt 8): 1611—22. PMID 11950880. 
  9. 9,0 9,1 9,2 9,3 9,4 9,5 Kneissl M, Pütter V, Szalay AA, Grummt F (2003). „Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells”. J. Mol. Biol. 327 (1): 111—28. PMID 12614612. doi:10.1016/s0022-2836(03)00079-2. 
  10. ^ Parker A, Gu Y, Mahoney W, Lee SH, Singh KK, Lu AL (2001). „Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair”. J. Biol. Chem. 276 (8): 5547—55. PMID 11092888. doi:10.1074/jbc.M008463200. 
  11. ^ Romanova LY, Willers H, Blagosklonny MV, Powell SN (2004). „The interaction of p53 with replication protein A mediates suppression of homologous recombination”. Oncogene. 23 (56): 9025—33. PMID 15489903. doi:10.1038/sj.onc.1207982. 
  12. ^ Riva F, Zuco V, Vink AA, Supino R, Prosperi E (2001). „UV-induced DNA incision and proliferating cell nuclear antigen recruitment to repair sites occur independently of p53-replication protein A interaction in p53 wild type and mutant ovarian carcinoma cells”. Carcinogenesis. 22 (12): 1971—8. PMID 11751427. doi:10.1093/carcin/22.12.1971. 
  13. ^ Shao RG, Cao CX, Zhang H, Kohn KW, Wold MS, Pommier Y (1999). „Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes”. EMBO J. 18 (5): 1397—406. PMC 1171229Слободан приступ. PMID 10064605. doi:10.1093/emboj/18.5.1397. 
  14. 14,0 14,1 Bochkareva E, Korolev S, Lees-Miller SP, Bochkarev A (2002). „Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA”. EMBO J. 21 (7): 1855—63. PMC 125950Слободан приступ. PMID 11927569. doi:10.1093/emboj/21.7.1855. 
  15. ^ Bochkareva E, Frappier L, Edwards AM, Bochkarev A (1998). „The RPA32 subunit of human replication protein A contains a single-stranded DNA-binding domain”. J. Biol. Chem. 273 (7): 3932—6. PMID 9461578. doi:10.1074/jbc.273.7.3932. 
  16. ^ Unsal-Kaçmaz K, Chastain PD, Qu PP, Minoo P, Cordeiro-Stone M, Sancar A, Kaufmann WK (2007). „The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement”. Mol. Cell. Biol. 27 (8): 3131—42. PMC 1899931Слободан приступ. PMID 17296725. doi:10.1128/MCB.02190-06. 
  17. ^ Yoo E, Kim BU, Lee SY, Cho CH, Chung JH, Lee CH (2005). „53BP1 is associated with replication protein A and is required for RPA2 hyperphosphorylation following DNA damage”. Oncogene. 24 (35): 5423—30. PMID 15856006. doi:10.1038/sj.onc.1208710. 
  18. ^ Li L, Lu X, Peterson CA, Legerski RJ (1995). „An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair”. Mol. Cell. Biol. 15 (10): 5396—402. PMC 230789Слободан приступ. PMID 7565690. doi:10.1128/mcb.15.10.5396. 

Literatura[уреди | уреди извор]