TRNK (guanin37-N1)-metiltransferaza
| TRNK (guanin37-N1)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.228 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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TRNK (guanin37-N1)-metiltransferaza (EC 2.1.1.228, TrmD, tRNK (m1G37) metiltransferaza, transfer RNK (m1G37) metiltransferaza, Trm5p, TRMT5, tRNK-(N1G37) metiltransferaza, MJ0883 (gen)) je enzim sa sistematskim imenom S-adenozil-L-metionin:tRNK (guanin37-N1)-metiltransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + guanin37 u tRNK S-adenozil-L-homocistein + N1-metilguanin37 u tRNK
Ovaj enzim je važan za održavanje korektnog okvira čitanja tokom translacije. Za razliku od TrmD iz Escherichia coli, koji preferentno prepoznaje G36pG37 motif, ljudski enzim (kodiran TRMT5 genom) takođe metiluje inozin u poziciji 37.
Reference[уреди | уреди извор]
- ^ Takeda, H., Toyooka, T., Ikeuchi, Y., Yokobori, S., Okadome, K., Takano, F., Oshima, T., Suzuki, T., Endo, Y. and Hori, H. (2006). „The substrate specificity of tRNA (m1G37) methyltransferase (TrmD) from Aquifex aeolicus”. Genes Cells. 11: 1353—1365. PMID 17121543.
- ^ Lee, C., Kramer, G., Graham, D.E. and Appling, D.R. (2007). „Yeast mitochondrial initiator tRNA is methylated at guanosine 37 by the Trm5-encoded tRNA (guanine-N1-)-methyltransferase”. J. Biol. Chem. 282: 27744—27753. PMID 17652090.
- ^ O'Dwyer, K., Watts, J.M., Biswas, S., Ambrad, J., Barber, M., Brule, H., Petit, C., Holmes, D.J., Zalacain, M. and Holmes, W.M. (2004). „Characterization of Streptococcus pneumoniae TrmD, a tRNA methyltransferase essential for growth”. J. Bacteriol. 186: 2346—2354. PMID 15060037.
- ^ Brule, H., Elliott, M., Redlak, M., Zehner, Z.E. and Holmes, W.M. (2004). „Isolation and characterization of the human tRNA-(N1G37) methyltransferase (TRM5) and comparison to the Escherichia coli TrmD protein”. Biochemistry. 43: 9243—9255. PMID 15248782.
- ^ Goto-Ito, S., Ito, T., Ishii, R., Muto, Y., Bessho, Y. and Yokoyama, S. (2008). „Crystal structure of archaeal RNA(m1G37)methyltransferase aTrm5”. Proteins. 72: 1274—1289. PMID 18384044.
- ^ Ahn, H.J., Kim, H.W., Yoon, H.J., Lee, B.I., Suh, S.W. and Yang, J.K. (2003). „Crystal structure of tRNA(m1G37)methyltransferase: insights into tRNA recognition”. EMBO J. 22: 2593—2603. PMID 12773376.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- TRNA+(guanine37-N1)-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
