Tauroursodezoksiholinska kiselina

Tauroursodezoksiholinska kiselina
Nazivi
	Drugi nazivi Tauro, Taurolite
Identifikacija
CAS broj	14605-22-2 ;
3D model (Jmol)	interaktivna slika;
ChemSpider	8024531 ;
DrugBank	DB08834;
KEGG	C16868 ;
PubChem C ID	9848818;
	SMILES C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2[C@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C; ; ; ; ; ;
Svojstva
Hemijska formula	C26H45NO6S
Molarna masa	499,71 g·mol−1
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	verifikuj (šta je ?)
	Reference infokutije

Tauroursodezoksiholinska kiselina (TUDCA) je ambifilna žučna kiselina. Ona je taurinska konjugatna forma ursodezoksiholinske kiseline (UDCA). TUDCA je kod čoveka prisutan u tragovima. Medvedi sadrže velike količine TUDCA u njihovoj žuči; UDCA i konjugati sačinjavaju oko 47% žuči kod američkog crnog medveda i do 76% kod azijskih medveda.^[4] TUDCA je korišćena u drevnim azijskim farmakopejama jer se smatralo da ima blagotvorno dejstvo. UDCA se proizvodi u nekoliko zemalja radi lečenja žučnog kamena i ciroze jetre. FDA nije odobrila primenu tauroursodezoksiholinske kiseline, dok je UDCA odobrena za lečenje primarne bilijarne ciroze.^[5]^[6].^[7]^[8]^[9]^[10]

Reference[уреди | уреди извор]

^ Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ Boatright, Jeffrey H.; Nickerson, John M.; Moring, Anisha G.; Pardue, Machelle T. (2009). „Bile acids in treatment of ocular disease”. Journal of Ocular Biology, Diseases, and Informatics. 2 (3): 149—159. PMC 2798994 . PMID 20046852. doi:10.1007/s12177-009-9030-x.
^ Boatright, Jeffrey H, Nickerson, John M, Moring, Anisha G, Pardue, Machelle T. (2009). „Bile acids in treatment of ocular disease”. J Ocul Biol Dis Infor. 2 (3): 149—159. PMC 2798994 . PMID 20046852. doi:10.1007/s12177-009-9030-x.
^ Duan, WJ, Zhang, FK, Ou XJ, Zhang, T, Wang, XM, Wang, Y, Cui, Y, Zhao, XY, Jia, JD (2011). „[The clinical profiles of primary biliary cirrhosis with a suboptimal biochemical response to ursodeoxycholic acid]”. Zhonghua Gan Zang Bing Za Zhi. 19 (2): 118—120. PMID 21492515. doi:10.3760/cma.j.issn.1007-3418.2011.02.011.
^ Schroeder A, Eckhardt U, Stieger B, Tynes R, Schteingart CD, Hofmann AF, Meier PJ, Hagenbuch B: Substrate specificity of the rat liver Na(+)-bile salt cotransporter in Xenopus laevis oocytes and in CHO cells. Am J Physiol. 1998 Feb;274(2 Pt 1):G370-5. PMID 9486191
^ Obici L, Cortese A, Lozza A, Lucchetti J, Gobbi M, Palladini G, Perlini S, Saraiva MJ, Merlini G: Doxycycline plus tauroursodeoxycholic acid for transthyretin amyloidosis: a phase II study. Amyloid. 2012 Jun;19 Suppl 1:34-6. doi: 10.3109/13506129.2012.678508. Epub 2012 May 2. PMID 22551192
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126. уреди
^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958. уреди

Spoljašnje veze[уреди | уреди извор]

Tauroursodeoxycholic acid

[1] Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[2] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[3] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[4] Boatright, Jeffrey H.; Nickerson, John M.; Moring, Anisha G.; Pardue, Machelle T. (2009). „Bile acids in treatment of ocular disease”. Journal of Ocular Biology, Diseases, and Informatics. 2 (3): 149—159. PMC 2798994 . PMID 20046852. doi:10.1007/s12177-009-9030-x.

[5] Boatright, Jeffrey H, Nickerson, John M, Moring, Anisha G, Pardue, Machelle T. (2009). „Bile acids in treatment of ocular disease”. J Ocul Biol Dis Infor. 2 (3): 149—159. PMC 2798994 . PMID 20046852. doi:10.1007/s12177-009-9030-x.

[6] Duan, WJ, Zhang, FK, Ou XJ, Zhang, T, Wang, XM, Wang, Y, Cui, Y, Zhao, XY, Jia, JD (2011). „[The clinical profiles of primary biliary cirrhosis with a suboptimal biochemical response to ursodeoxycholic acid]”. Zhonghua Gan Zang Bing Za Zhi. 19 (2): 118—120. PMID 21492515. doi:10.3760/cma.j.issn.1007-3418.2011.02.011.

[7] Schroeder A, Eckhardt U, Stieger B, Tynes R, Schteingart CD, Hofmann AF, Meier PJ, Hagenbuch B: Substrate specificity of the rat liver Na(+)-bile salt cotransporter in Xenopus laevis oocytes and in CHO cells. Am J Physiol. 1998 Feb;274(2 Pt 1):G370-5. PMID 9486191

[8] Obici L, Cortese A, Lozza A, Lucchetti J, Gobbi M, Palladini G, Perlini S, Saraiva MJ, Merlini G: Doxycycline plus tauroursodeoxycholic acid for transthyretin amyloidosis: a phase II study. Amyloid. 2012 Jun;19 Suppl 1:34-6. doi: 10.3109/13506129.2012.678508. Epub 2012 May 2. PMID 22551192

[9] Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126. уреди

[10] David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958. уреди

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]