Tromboksan-A sintaza

Из Википедије, слободне енциклопедије
Tromboksan A sintaza 1 (trombocitna)
Identifikatori
Simboli TBXAS1; BDPLT14; CYP5; CYP5A1; GHOSAL; THAS; TS; TXAS; TXS
Vanjski ID OMIM274180 MGI98497 HomoloGene55549 GeneCards: TBXAS1 Gene
EC broj 5.3.99.5
Pregled RNK izražavanja
PBB GE TBXAS1 208130 s at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 6916 21391
Ensembl ENSG00000059377 ENSMUSG00000029925
UniProt P24557 P36423
RefSeq (mRNA) NM_001061.4 NM_011539.3
RefSeq (protein) NP_001052.2 NP_035669.3
Lokacija (UCSC) Chr 7:
139.48 - 139.72 Mb
Chr 6:
38.88 - 39.08 Mb
PubMed pretraga [1] [2]

Tromboksan-A sintaza 1 (EC 5.3.99.5, trombocit, citohrom P450, familija 5, potfamilija A), takođe poznata kao TBXAS1, je enzim koji je kod ljudi kodiran TBXAS1 genom.[1][2][3]

Reference[уреди]

  1. „Entrez Gene: TBXAS1 thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A)”. 
  2. Yokoyama C, Miyata A, Ihara H, Ullrich V, Tanabe T (1991). „Molecular cloning of human platelet thromboxane A synthase”. Biochem. Biophys. Res. Commun. 178 (3): 1479—1484. doi:10.1016/0006-291X(91)91060-P. PMID 1714723. 
  3. Baek SJ, Lee KD, Shen RF (1996). „Genomic structure and polymorphism of the human thromboxane synthase-encoding gene”. Gene. 173 (2): 251—256. doi:10.1016/0378-1119(95)00881-0. PMID 8964509. 

Literatura[уреди]

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  • Wang LH, Kulmacz RJ (2003). „Thromboxane synthase: structure and function of protein and gene”. Prostaglandins Other Lipid Mediat. 68-69: 409—422. doi:10.1016/S0090-6980(02)00045-X. PMID 12432933. 
  • Itoh S; Yanagimoto T; Tagawa S; et al. (1992). „Genomic organization of human fetal specific P-450IIIA7 (cytochrome P-450HFLa)-related gene(s) and interaction of transcriptional regulatory factor with its DNA element in the 5' flanking region”. Biochim. Biophys. Acta. 1130 (2): 133—8. PMID 1562592. 
  • Yokoyama C; Miyata A; Ihara H; et al. (1991). „Molecular cloning of human platelet thromboxane A synthase”. Biochem. Biophys. Res. Commun. 178 (3): 1479—1484. doi:10.1016/0006-291X(91)91060-P. PMID 1714723. 
  • Ohashi K; Ruan KH; Kulmacz RJ; et al. (1992). „Primary structure of human thromboxane synthase determined from the cDNA sequence”. J. Biol. Chem. 267 (2): 789—93. PMID 1730669. 
  • Jones DA, Fitzpatrick FA, Malcolm KC (1991). „Thromboxane A2 synthesis in human erythroleukemia cells”. Biochem. Biophys. Res. Commun. 180 (1): 8—14. doi:10.1016/S0006-291X(05)81247-1. PMID 1930241. 
  • Wang LH, Ohashi K, Wu KK (1991). „Isolation of partial complementary DNA encoding human thromboxane synthase”. Biochem. Biophys. Res. Commun. 177 (1): 286—291. doi:10.1016/0006-291X(91)91980-Q. PMID 2043115. 
  • Nüsing R, Schneider-Voss S, Ullrich V (1990). „Immunoaffinity purification of human thromboxane synthase”. Arch. Biochem. Biophys. 280 (2): 325—330. doi:10.1016/0003-9861(90)90337-X. PMID 2195994. 
  • Mestel F; Oetliker O; Beck E; et al. (1980). „Severe bleeding associated with defective thromboxane synthetase”. Lancet. 1 (8160): 157. doi:10.1016/S0140-6736(80)90642-X. PMID 6101498. 
  • Miyata A; Yokoyama C; Ihara H; et al. (1994). „Characterization of the human gene (TBXAS1) encoding thromboxane synthase”. Eur. J. Biochem. 224 (2): 273—279. doi:10.1111/j.1432-1033.1994.00273.x. PMID 7925341. 
  • Wang LH, Tazawa R, Lang AQ, Wu KK (1995). „Alternate splicing of human thromboxane synthase mRNA”. Arch. Biochem. Biophys. 315 (2): 273—278. doi:10.1006/abbi.1994.1500. PMID 7986068. 
  • Maruyama K, Sugano S (1994). „Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1–2): 171—174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Lee KD, Baek SJ, Shen RF (1994). „Cloning and characterization of the human thromboxane synthase gene promoter”. Biochem. Biophys. Res. Commun. 201 (1): 379—387. doi:10.1006/bbrc.1994.1712. PMID 8198598. 
  • Chase MB; Baek SJ; Purtell DC; et al. (1993). „Mapping of the human thromboxane synthase gene (TBXAS1) to chromosome 7q34-q35 by two-color fluorescence in situ hybridization”. Genomics. 16 (3): 771—773. doi:10.1006/geno.1993.1264. PMID 8325653. 
  • Ruan KH, Wang LH, Wu KK, Kulmacz RJ (1993). „Amino-terminal topology of thromboxane synthase in the endoplasmic reticulum”. J. Biol. Chem. 268 (26): 19483—90. PMID 8366093. 
  • Tazawa R; Green ED; Ohashi K; et al. (1996). „Characterization of the complete genomic structure of human thromboxane synthase gene and functional analysis of its promoter”. Arch. Biochem. Biophys. 334 (2): 349—356. doi:10.1006/abbi.1996.0464. PMID 8900410. 
  • Baek SJ, Lee KD, Shen RF (1996). „Genomic structure and polymorphism of the human thromboxane synthase-encoding gene”. Gene. 173 (2): 251—256. doi:10.1016/0378-1119(95)00881-0. PMID 8964509. 
  • Suzuki Y; Yoshitomo-Nakagawa K; Maruyama K; et al. (1997). „Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library”. Gene. 200 (1–2): 149—156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
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