Vankomicin

Из Википедије, слободне енциклопедије
Vankomicin
Vancomycin.svg
Vancomycin ball-and-stick.png
Klinički podaci
Prodajno ime Vancocin, Vancocin HCL, Vancoled, Vancor
Drugs.com Monografija
Način primene Oralno, intravenozno
Farmakokinetički podaci
Poluvreme eliminacije 6 h
Izlučivanje Renalno
Identifikatori
CAS broj 1404-90-6 ДаY
ATC kod A07AA09 (WHO) , J01XA01
PubChem CID 14969
DrugBank DB00512 ДаY
ChemSpider 389935 ДаY
KEGG C06689 ДаY
ChEBI CHEBI:28001 ДаY
ChEMBL CHEMBL262777 ДаY
Hemijski podaci
Formula C66H75Cl2N9O24
Molarna masa 1449,254

Vankomicin je organsko jedinjenje, koje sadrži 66 atoma ugljenika i ima molekulsku masu od 1449,254 Da.[1][2][3][4][5][6][7][8]

Osobine[уреди]

Osobina Vrednost
Broj akceptora vodonika 26
Broj donora vodonika 19
Broj rotacionih veza 13
Particioni koeficijent[9] (ALogP) -2,9
Rastvorljivost[10] (logS, log(mol/L)) -9,9
Polarna površina[11] (PSA, Å2) 530,5

Reference[уреди]

  1. Schäfer, Martina, Thomas R Schneider, and George M Sheldrick. 1996. Crystal structure of vancomycin. Structure 4, no. 12 (December 15): 1509-1515. DOI:10.1016/S0969-2126(96)00156-6:http://dx.doi.org/10.1016/S0969-2126(96)00156-6.
  2. Levine DP: Vancomycin: a history. Clin Infect Dis. 2006 Jan 1;42 Suppl 1:S5-12. PMID 16323120
  3. Small PM, Chambers HF: Vancomycin for Staphylococcus aureus endocarditis in intravenous drug users. Antimicrob Agents Chemother. 1990 Jun;34(6):1227-31. PMID 2393284
  4. Gonzalez C, Rubio M, Romero-Vivas J, Gonzalez M, Picazo JJ: Bacteremic pneumonia due to Staphylococcus aureus: A comparison of disease caused by methicillin-resistant and methicillin-susceptible organisms. Clin Infect Dis. 1999 Nov;29(5):1171-7. PMID 10524959
  5. Sivagnanam S, Deleu D: Red man syndrome. Crit Care. 2003 Apr;7(2):119-20. Epub 2002 Dec 23. PMID 12720556
  6. Cantu TG, Yamanaka-Yuen NA, Lietman PS: Serum vancomycin concentrations: reappraisal of their clinical value. Clin Infect Dis. 1994 Apr;18(4):533-43. PMID 8038306
  7. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709Слободан приступ. PMID 21059682. doi:10.1093/nar/gkq1126. 
  8. David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889Слободан приступ. PMID 18048412. doi:10.1093/nar/gkm958. 
  9. Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o. 
  10. Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  11. Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

Literatura[уреди]

Spoljašnje veze[уреди]

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