23S rRNK (guanozin2251-2'-O)-metiltransferaza
| 23S rRNK (guanozin2251-2'-O)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.185 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
23S rRNK (guanozin2251-2'-O)-metiltransferaza (EC 2.1.1.185, rlmB (gen), yifH (gen)) je enzim sa sistematskim imenom S-adenozil-L-metionin:23S rRNK (guanozin2251-2'-O-)-metiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + guanozin2251 u 23S rRNK S-adenozil-L-homocistein + 2'-O-metilguanozin2251 u 23S rRNK
Enzim katalizuje metilaciju guanozina2251. Ta modifikacija je konzervirana u peptidiltransferaznom domenu 23S rRNK.
Reference[уреди | уреди извор]
- ^ Lovgren, J.M. & Wikstrom, P.M. (2001). „The rlmB gene is essential for formation of Gm2251 in 23S rRNA but not for ribosome maturation in Escherichia coli”. J. Bacteriol. 183: 6957—6960. PMID 11698387.
- ^ Michel, G., Sauve, V., Larocque, R., Li, Y., Matte, A. and Cygler, M. (2002). „The structure of the RlmB 23S rRNA methyltransferase reveals a new methyltransferase fold with a unique knot”. Structure. 10: 1303—1315. PMID 12377117.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- 23S+rRNA+(guanosine2251-2'-O)-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
