Acil-KoA dehidrogenaza veoma dugog lanca
| Acil-KoA dehidrogenaza veoma dugog lanca | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Acil-KoA dehidrogenaza veoma dugog lanca dimer, Human | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.3.8.9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Acil-KoA dehidrogenaza veoma dugog lanca (EC 1.3.8.9, ACADVL (gen).) je enzim sa sistematskim imenom acil-KoA veoma dugog lanca:elektron-transfer flavoprotein 2,3-oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acil-KoA veoma dugog lanca + elektron-transfer flavoprotein trans-2,3-dehidroacil-KoA veoma dugog lanca + redukovani elektron-transfer flavoprotein
Ovaj enzim sadrži FAD kao prostetičku grupu. On je jedan od nekoliko enzima koji katalizuju prvi kora u beta oksidaciji masnih kiselina.
Reference[уреди | уреди извор]
- ^ Izai, K., Uchida, Y., Orii, T., Yamamoto, S. and Hashimoto, T. (1992). „Novel fatty acid β-oxidation enzymes in rat liver mitochondria. I. Purification and properties of very-long-chain acyl-coenzyme A dehydrogenase”. J. Biol. Chem. 267: 1027—1033. PMID 1730632.
- ^ Aoyama, T., Souri, M., Ushikubo, S., Kamijo, T., Yamaguchi, S., Kelley, R.I., Rhead, W.J., Uetake, K., Tanaka, K. and Hashimoto, T. (1995). „Purification of human very-long-chain acyl-coenzyme A dehydrogenase and characterization of its deficiency in seven patients”. J. Clin. Invest. 95: 2465—2473. PMID 7769092.
- ^ McAndrew, R.P., Wang, Y., Mohsen, A.W., He, M., Vockley, J. and Kim, J.J. (2008). „Structural basis for substrate fatty acyl chain specificity: crystal structure of human very-long-chain acyl-CoA dehydrogenase”. J. Biol. Chem. 283: 9435—9443. PMID 18227065.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Very-long-chain+acyl-CoA+dehydrogenase на US National Library of Medicine Medical Subject Headings (MeSH)
