Akridon sintaza
| Akridon sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.159 | ||||||||
| CAS broj | 99085-53-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Akridon sintaza (EC 2.3.1.159) je enzim sa sistematskim imenom malonil-KoA:N-metilantraniloil-KoA maloniltransferaza (ciklizacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 3 malonil-KoA + N-metilantraniloil-KoA 4 KoA + 1,3-dihidroksi-N-metilakridon + 3 CO2
Ovaj enzim pripada superfamiliji biljnih poliketidnih sintaza.
Reference[уреди | уреди извор]
- ^ Baumert, A., Maier, W., Gröger, D. and Deutzmann, R. (1994). „Purification and properties of acridone synthase from cell suspension cultures of Ruta graveolens L”. Z. Naturforsch. C: Biosci. 49: 26—32. PMID 8148006.
- ^ Maier, W., Baumert, A., Schumann, B., Furukawa, H. and Gröger, D. (1993). „Synthesis of 1,3-dihydroxy-N-methylacridone and its conversion to rutacridone by cell-free extracts of Ruta-graveolens cell cultures”. Phytochemistry. 32: 691—698.
- ^ Lukačin, R., Springob, K., Urbanke, C., Ernwein, C., Schroder, G., Schroder, J. and Matern, U. (1999). „Native acridone synthases I and II from Ruta graveolens L. form homodimers”. FEBS Lett. 448: 135—140. PMID 10217426.
- ^ Junghanns, K.T., Kneusel, R.E., Groger, D. and Matern, U. (1998). „Differential regulation and distribution of acridone synthase in Ruta graveolens”. Phytochemistry. 49: 403—411. PMID 9747538.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Acridone+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
