Alken monooksigenaza
| Alken monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.69 | ||||||||
| CAS broj | 63439-50-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Alken monooksigenaza (EC 1.14.13.69, alkenska epoksigenaza) je enzim sa sistematskim imenom alken,NADH:kiseonik oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- propen + NADH + H+ + O2 1,2-epoksipropan + NAD+ + H2O
Enzim iz Xanthobacter sp. vrste Py2 je multikomponentni enzim koji sadrži (1) NADH reduktazu, koja pruža reduktant za O2 aktivaciju; (2) feredoksina Riskijevog tipa, koji je protein elektronskog transfera; (3) oksigenazu, koja sadrži katalitički centar za alkensku epoksidaciju i (4) malog proteina nepoznate funkcije koji je esencijalan za aktivnost.
Reference[уреди | уреди извор]
- ^ Small, F.J. & Ensign, S.A. (1997). „Alkene monooxygenase from Xanthobacter strain Py2: purification and characterization of a four-component system central to the bacterial metabolism of aliphatic alkenes”. J. Biol. Chem. 272: 24913—24920. PMID 9312093.
- ^ Zhou, N.Y., Jenkins, A., Chion, C.K.N.C.K. and Leak, D.J. (1999). „The alkene monooxygenase from Xanthobacter strain Py2 is closely related to aromatic monooxygenases and catalyzes aromatic monohydroxylation of benzene, toluene, and phenol”. Appl. Environ. Microbiol. 65: 1589—1595. PMID 10103255.
- ^ Gallagher, S.C., Cammack, R. and Dalton, H. (1997). „Alkene monooxygenase from Nocardia corallina B-276 is a member of the class of dinuclear iron proteins capable of stereospecific epoxygenation reactions”. Eur. J. Biochem. 247: 635—641. PMID 9266707.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Alkene+monooxygenase на US National Library of Medicine Medical Subject Headings (MeSH)
