Artemizinski aldehid Delta11(13)-reduktaza
| Artemizinski aldehid Delta11(13)-reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.1.92 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Artemizinski aldehid Delta11(13)-reduktaza (EC 1.3.1.92, Dbr2) je enzim sa sistematskim imenom artemizinski aldehid:NADP+ oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (11R)-dihidroartemizinski aldehid + NADP+ artemizinski aldehid + NADPH + H+
Ovaj enzim je kloniran iz Artemisia annua. Osim redukcije artemizinskog aldehida, on takođe ima sposobnost da u manjoj meri redukuje artemizinski alkohol i artemizinsku kiselinu.
Reference[уреди | уреди извор]
- ^ Bertea, C.M., Freije, J.R., van der Woude, H., Verstappen, F.W., Perk, L., Marquez, V., De Kraker, J.W., Posthumus, M.A., Jansen, B.J., de Groot, A., Franssen, M.C. and Bouwmeester, H.J. (2005). „Identification of intermediates and enzymes involved in the early steps of artemisinin biosynthesis in Artemisia annua”. Planta Med. 71: 40—47. PMID 15678372.
- ^ Zhang, Y., Teoh, K.H., Reed, D.W., Maes, L., Goossens, A., Olson, D.J., Ross, A.R. and Covello, P.S. (2008). „The molecular cloning of artemisinic aldehyde Δ11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua”. J. Biol. Chem. 283: 21501—21508. PMID 18495659.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Artemisinic+aldehyde+Delta11(13)-reductase на US National Library of Medicine Medical Subject Headings (MeSH)
