Azotsuboksid reduktaza (NAD(P), formira azot monoksid)
| Azotsuboksid reduktaza (NAD(P), formira azot monoksid) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.7.1.14 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Azotsuboksid reduktaza (NAD(P), formira azot monoksid) (EC 1.7.1.14, fungalna azotno suboksidna reduktaza, citohrom P450nor, NOR (nespecifična)) je enzim sa sistematskim imenom azot monoksid:NAD(P) oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- N2O + NAD(P)+ +H2O 2 NO + NAD(P)H + H+
Ovaj enzim je hem-tiolatni protein (P450). Enzim iz Fusarium oksisporum koristi samo NADH, dok izozim iz Trichosporon cutaneum koristi NADH i NADPH.
Reference[уреди | уреди извор]
- ^ Shoun, H. & Tanimoto, T. (1991). „Denitrification by the fungus Fusarium oxysporum and involvement of cytochrome P-450 in the respiratory nitrite reduction”. J. Biol. Chem. 266: 11078—11082. PMID 2040619.
- ^ Shiro, Y., Fujii, M., Iizuka, T., Adachi, S., Tsukamoto, K., Nakahara, K. and Shoun, H. (1995). „Spectroscopic and kinetic studies on reaction of cytochrome P450nor with nitric oxide. Implication for its nitric oxide reduction mechanism”. J. Biol. Chem. 270: 1617—1623. PMID 7829493.
- ^ Zhang, L., Kudo, T., Takaya, N. and Shoun, H. (2002). „The B′ helix determines cytochrome P450nor specificity for the electron donors NADH and NADPH”. J. Biol. Chem. 277: 33842—33847. PMID 12105197.
- ^ Oshima, R., Fushinobu, S., Su, F., Zhang, L., Takaya, N. and Shoun, H. (2004). „Structural evidence for direct hydride transfer from NADH to cytochrome P450nor”. J. Mol. Biol. 342: 207—217. PMID 15313618.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Nitric+oxide+reductase+(NAD(P),+nitrous+oxide-forming) на US National Library of Medicine Medical Subject Headings (MeSH)
