Beta-ketoacil-(acil-nosilac-protein) sintaza III
| Beta-ketoacil-(acil-nosilac-protein) sintaza III | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.180 | ||||||||
| CAS broj | 1048646-78-1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Beta-ketoacil-(acil-nosilac-protein) sintaza III (EC 2.3.1.180, 3-oksoacil:ACP sintaza III, 3-ketoacil-acil nosilac protein sintaza III, KASIII, KAS III, FabH, beta-ketoacil-acil nosilac protein sintaza III, beta-ketoacil-ACP sintaza III, beta-ketoacil (acil nosilac protein) sintaza III, acetil-KoA:malonil-(acil-nosilac-protein) C-aciltransferaza) je enzim sa sistematskim imenom acetil-KoA:malonil-(acil-nosilac protein) C-aciltransferaza.[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acetil-KoA + malonil-[acil-nosilac protein] acetoacetil-[acil-nosilac protein] + KoA + CO2
Ovaj enzim učestvuje u sistemu biosinteze disociranih masnih kiselina kod biljki i bakterija.
Reference[уреди | уреди извор]
- ^ Tsay, J.T., Oh, W., Larson, T.J., Jackowski, S. and Rock, C.O. (1992). „Isolation and characterization of the β-ketoacyl-acyl carrier protein synthase III gene (fabH) from Escherichia coli K-12”. J. Biol. Chem. 267: 6807—6814. PMID 1551888.
- ^ Han, L., Lobo, S. and Reynolds, K.A. (1998). „Characterization of β-ketoacyl-acyl carrier protein synthase III from Streptomyces glaucescens and its role in initiation of fatty acid biosynthesis”. J. Bacteriol. 180: 4481—4486. PMID 9721286.
- ^ Khandekar, S.S., Gentry, D.R., Van Aller, G.S., Warren, P., Xiang, H., Silverman, C., Doyle, M.L., Chambers, P.A., Konstantinidis, A.K., Brandt, M., Daines, R.A. and Lonsdale, J.T. (2001). „Identification, substrate specificity, and inhibition of the Streptococcus pneumoniae β-ketoacyl-acyl carrier protein synthase III (FabH)”. J. Biol. Chem. 276: 30024—30030. PMID 11375394.
- ^ Choi, K.H., Kremer, L., Besra, G.S. and Rock, C.O. (2000). „Identification and substrate specificity of β-ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis”. J. Biol. Chem. 275: 28201—28207. PMID 10840036.
- ^ Qiu, X., Choudhry, A.E., Janson, C.A., Grooms, M., Daines, R.A., Lonsdale, J.T. and Khandekar, S.S. (2005). „Crystal structure and substrate specificity of the β-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus”. Protein Sci. 14: 2087—2094. PMID 15987898.
- ^ Li, Y., Florova, G. and Reynolds, K.A. (2005). „Alteration of the fatty acid profile of Streptomyces coelicolor by replacement of the initiation enzyme 3-ketoacyl acyl carrier protein synthase III (FabH)”. J. Bacteriol. 187: 3795—3799. PMID 15901703.
- ^ Cronan, J.E., Jr. & Rock, C.O. (1996). „Biosynthesis of membrane lipids”. Ур.: Neidhardt, F.C. Escherichia coli and Salmonella: Cellular and Molecular Biology. 1 (2nd изд.). Washington, DC: ASM Press. стр. 612—636.
Литература[уреди | уреди извор]
- Cronan, J.E., Jr. & Rock, C.O. (1996). „Biosynthesis of membrane lipids”. Ур.: Neidhardt, F.C. Escherichia coli and Salmonella: Cellular and Molecular Biology. 1 (2nd изд.). Washington, DC: ASM Press. стр. 612—636.
Spoljašnje veze[уреди | уреди извор]
- Beta-ketoacyl-(acyl-carrier-protein)+synthase+III на US National Library of Medicine Medical Subject Headings (MeSH)
