Ditrans,policis-poliprenil difosfat sintaza ((2E,6E)-farnezil difosfat specifična)
| Ditrans,policis-poliprenil difosfat sintaza ((2E,6E)-farnezil difosfat specifična) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.87 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Ditrans,policis-poliprenil difosfat sintaza ((2E,6E)-farnezil difosfat specifična) (EC 2.5.1.87, RER2, Rer2p, Rer2p Z-preniltransferaza, Srt1p, Srt2p Z-preniltransferaza, ACPT, dehidrodolihil difosfatna sintaza 1) je enzim sa sistematskim imenom (2E,6E)-farnezil-difosfat:izopentenil-difosfat cistransferaza (dodaje 10--55 izopentenilnih jedinica).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (2E,6E)-farnezil difosfat + n izopentenil difosfat n difosfat + ditrans,policis-poliprenil difosfat (n = 10--55)
Ovaj enzim učestvuje u biosintezi dolihola (dugolančanog poliprenola) sa zasićenim alfa-izoprenskim jedinicama.
Reference[уреди | уреди извор]
- ^ Sato, M., Fujisaki, S., Sato, K., Nishimura, Y. and Nakano, A. (2001). „Yeast Saccharomyces cerevisiae has two cis-prenyltransferases with different properties and localizations. Implication for their distinct physiological roles in dolichol synthesis”. Genes Cells. 6: 495—506. PMID 11442630.
- ^ Poznanski, J. & Szkopinska, A. (2007). „Precise bacterial polyprenol length control fails in Saccharomyces cerevisiae”. Biopolymers. 86: 155—164. PMID 17345630.
- ^ Sato, M., Sato, K., Nishikawa, S., Hirata, A., Kato, J. and Nakano, A. (1999). „The yeast RER2 gene, identified by endoplasmic reticulum protein localization mutations, encodes cis-prenyltransferase, a key enzyme in dolichol synthesis”. Mol. Cell Biol. 19: 471—483. PMID 9858571.
- ^ Oh, S.K., Han, K.H., Ryu, S.B. and Kang, H. (2000). „Molecular cloning, expression, and functional analysis of a cis-prenyltransferase from Arabidopsis thaliana. Implications in rubber biosynthesis”. J. Biol. Chem. 275: 18482—18488. PMID 10764783.
- ^ Cunillera, N., Arro, M., Fores, O., Manzano, D. and Ferrer, A. (2000). „Characterization of dehydrodolichyl diphosphate synthase of Arabidopsis thaliana, a key enzyme in dolichol biosynthesis”. FEBS Lett. 477: 170—174. PMID 10908715.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Ditrans,polycis-polyprenyl+diphosphate+synthase+((2E,6E)-farnesyl+diphosphate+specific) на US National Library of Medicine Medical Subject Headings (MeSH)
