Dugolančani enoil-KoA reduktaza
| Dugolančani enoil-KoA reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.1.93 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Dugolančani enoil-KoA reduktaza (EC 1.3.1.93, TSC13 (gen), CER10 (gen)) je enzim sa sistematskim imenom dugolančani acil-KoA:NADP+ oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- dugolančani acil-KoA + NADP+ dugolančani trans-2,3-dehidroacil-KoA + NADPH + H+
Ovaj enzim je četvrta komponenta elongaze, mikrozomalnog proteinskog kompleksa koji je odgovoran za produžavanje palmitoila KoA i stearoila KoA (kao i njihovih modifikovanih formi) do dugolančanih acil KoA molekula.
Reference[уреди | уреди извор]
- ^ Kohlwein, S.D., Eder, S., Oh, C.S., Martin, C.E., Gable, K., Bacikova, D. and Dunn, T. (2001). „Tsc13p is required for fatty acid elongation and localizes to a novel structure at the nuclear-vacuolar interface in Saccharomyces cerevisiae”. Mol. Cell Biol. 21: 109—125. PMID 11113186.
- ^ Gable, K., Garton, S., Napier, J.A. and Dunn, T.M. (2004). „Functional characterization of the Arabidopsis thaliana orthologue of Tsc13p, the enoyl reductase of the yeast microsomal fatty acid elongating system”. J. Exp. Bot. 55: 543—545. PMID 14673020.
- ^ Kvam, E., Gable, K., Dunn, T.M. and Goldfarb, D.S. (2005). „Targeting of Tsc13p to nucleus-vacuole junctions: a role for very-long-chain fatty acids in the biogenesis of microautophagic vesicles”. Mol. Biol. Cell. 16: 3987—3998. PMID 15958487.
- ^ Zheng, H., Rowland, O. and Kunst, L. (2005). „Disruptions of the Arabidopsis Enoyl-CoA reductase gene reveal an essential role for very-long-chain fatty acid synthesis in cell expansion during plant morphogenesis”. Plant Cell. 17: 1467—1481. PMID 15829606.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Very-long-chain+enoyl-CoA+reductase на US National Library of Medicine Medical Subject Headings (MeSH)
