Feredoksin:tioredoksin reduktaza
| Feredoksin:tioredoksin reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.8.7.2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Feredoksin:tioredoksin reduktaza (EC 1.8.7.2, feredoksin:tioredoksin-reduktaza) je enzim sa sistematskim imenom feredoksin:tioredoksin disulfid oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju:
- 2 redukovani feredoksin + tioredoksin disulfid 2 oksidovani feredoksin + tioredoksin + 2 H+
Ovaj enzim sadrži [4Fe-4S] klaster i disulfid. On formira mešoviti disulfid sa tioredoksinom na jednoj strani, dok je na drugoj strani mesto vezivanja feredoksina, što omogućava dva jednoelektronska transfera.
Reference[уреди | уреди извор]
- ^ Buchanan, B.B. (1991). „Regulation of CO2 assimilation in oxygenic photosynthesis: the ferredoxin/thioredoxin system. Perspective on its discovery, present status, and future development”. Arch. Biochem. Biophys. 288: 1—9. PMID 1910303.
- ^ Chow, L.P., Iwadate, H., Yano, K., Kamo, M., Tsugita, A., Gardet-Salvi, L., Stritt-Etter, A.L. and Schurmann, P. (1995). „Amino acid sequence of spinach ferredoxin:thioredoxin reductase catalytic subunit and identification of thiol groups constituting a redox-active disulfide and a [4Fe-4S] cluster”. Eur. J. Biochem. 231: 149—156. PMID 7628465.
- ^ Staples, C.R., Ameyibor, E., Fu, W., Gardet-Salvi, L., Stritt-Etter, A.L., Schurmann, P., Knaff, D.B. and Johnson, M.K. (1996). „The function and properties of the iron-sulfur center in spinach ferredoxin: thioredoxin reductase: a new biological role for iron-sulfur clusters”. Biochemistry. 35: 11425—11434. PMID 8784198.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Ferredoxin:thioredoxin+reductase на US National Library of Medicine Medical Subject Headings (MeSH)
