Fosfometilpirimidinska sintaza
| Fosfometilpirimidinska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.1.99.17 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Fosfometilpirimidinska sintaza (EC 4.1.99.17, thiC (gen)) je enzim sa sistematskim imenom 5-amino-1-(5-fosfo-D-ribozil)imidazol format-lijaza (dekarboksilacija, formira 4-amino-2-metil-5-fosfometilpirimidin).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 5-amino-1-(5-fosfo-D-ribozil)imidazol + S-adenozil-L-metionin
4-amino-2-metil-5-fosfometilpirimidin + 5'-dezoksiadenozin + L-metionin + format + CO
Ovaj enzim sadrži 4Fe-4S klaster.
Reference[уреди | уреди извор]
- ^ Chatterjee, A., Li, Y., Zhang, Y., Grove, T.L., Lee, M., Krebs, C., Booker, S.J., Begley, T.P. and Ealick, S.E. (2008). „Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily”. Nat. Chem. Biol. 4: 758—765. PMID 18953358.
- ^ Martinez-Gomez, N.C., Poyner, R.R., Mansoorabadi, S.O., Reed, G.H. and Downs, D.M. (2009). „Reaction of AdoMet with ThiC generates a backbone free radical”. Biochemistry. 48: 217—219. PMID 19113839.
- ^ Chatterjee, A., Hazra, A.B., Abdelwahed, S., Hilmey, D.G. and Begley, T.P. (2010). „A "radical dance" in thiamin biosynthesis: mechanistic analysis of the bacterial hydroxymethylpyrimidine phosphate synthase”. Angew. Chem. Int. Ed. Engl. 49: 8653—8656. PMID 20886485.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Phosphomethylpyrimidine+synthase на US National Library of Medicine Medical Subject Headings (MeSH)