Glicin C-acetiltransferaza
| Glicin C-acetiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.29 | ||||||||
| CAS broj | 37257-11-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Glicin C-acetiltransferaza (EC 2.3.1.29, 2-amino-3-ketobutirat KoA ligaza, 2-amino-3-ketobutirat koenzim A ligaza, 2-amino-3-ketobutirat-KoA ligaza, glicin acetiltransferaza, aminoaceton sintaza, aminoaceton sintetaza, KBL, AKB ligaza) je enzim sa sistematskim imenom acetil-KoA:glicin C-acetiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acetil-KoA + glicin KoA + L-2-amino-3-oksobutanoat
Ovaj piridoksal-fosfat-zavisni enzim deluje zajedno sa EC 1.1.1.103, L-treonin 3-dehidrogenazom, tokom degradacije treonina čime se formira glicin.
Reference[уреди | уреди извор]
- ^ McGilvray, D. & Morris, J.G. (1969). „U'tilization of L-threonine by a species of Arthrobacter. A novel catabolic role for "aminoacetone synthase"”. Biochem. J. 112: 657—671. PMID 5821726.
- ^ Mukherjee, J.J. & Dekker, E.E. (1987). „Purification, properties, and N-terminal amino acid sequence of homogeneous Escherichia coli 2-amino-3-ketobutyrate CoA ligase, a pyridoxal phosphate-dependent enzyme”. J. Biol. Chem. 262: 14441—14447. PMID 3117785.
- ^ Edgar, A.J. & Polak, J.M. (2000). „Molecular cloning of the human and murine 2-amino-3-ketobutyrate coenzyme A ligase cDNAs”. Eur. J. Biochem. 267: 1805—1812. PMID 10712613.
- ^ Schmidt, A., Sivaraman, J., Li, Y., Larocque, R., Barbosa, J.A., Smith, C., Matte, A., Schrag, J.D. and Cygler, M. (2001). „Three-dimensional structure of 2-amino-3-ketobutyrate CoA ligase from Escherichia coli complexed with a PLP-substrate intermediate: inferred reaction mechanism”. Biochemistry. 40: 5151—5160. PMID 11318637.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Glycine+C-acetyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
