Glukozamin-1-fosfat N-acetiltransferaza
| Glukozamin-1-fosfat N-acetiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.157 | ||||||||
| CAS broj | 9031-91-8 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Glukozamin-1-fosfat N-acetiltransferaza (EC 2.3.1.157) je enzim sa sistematskim imenom acetil-KoA:alfa-D-glukozamin-1-fosfat N-acetiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acetil-KoA + alfa-D-glukozamin 1-fosfat KoA + N-acetil-alfa-D-glukozamin 1-fosfat
Enzim iz nekoliko bakterija (e.g., Escherichia coli, Bacillus subtilis i Hemophilus influenzae) je bifunkcionalan i takođe deluje kao enzim EC 2.7.7.23, UDP-N-acetilglukozaminska difosforilaza.
Reference[уреди | уреди извор]
- ^ Mengin-Lecreulx, D. & van Heijenoort, J. (1994). „Copurification of glucosamine-1-phosphate acetyltransferase and N-acetylglucosamine-1-phosphate uridyltransferase activities of Escherichia coli: characterization of the glmU gene product as a bifunctional enzyme catalyzing two subsequent steps in the pathway for UDP-N-acetylglucosamine synthesis”. J. Bacteriol. 176: 5788—5795. PMID 8083170.
- ^ Gehring, A.M., Lees, W.J., Mindiola, D.J., Walsh, C.T. and Brown, E.D. (1996). „Acetyltransfer precedes uridylyltransfer in the formation of UDP-N-acetylglucosamine in separable active sites of the bifunctional GlmU protein of Escherichia coli”. Biochemistry. 35: 579—585. PMID 8555230.
- ^ Olsen, L.R. & Roderick, S.L. (2001). „Structure of the Escherichia coli GlmU pyrophosphorylase and acetyltransferase active sites”. Biochemistry. 40: 1913—1921. PMID 11329257.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Glucosamine-1-phosphate+N-acetyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
