Heksaprenildihidroksibenzoat metiltransferaza
| Heksaprenildihidroksibenzoat metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.114 | ||||||||
| CAS broj | 139569-31-6 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Heksaprenildihidroksibenzoat metiltransferaza (EC 2.1.1.114, 3,4-dihidroksi-5-heksaprenilbenzoatna metiltransferaza, dihidroksiheksaprenilbenzoatna metiltransferaza, COQ3 (gen), Coq3 O-metiltransferaza, DHHB O-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:3,4-dihidroksi-5-sve-trans-poliprenilbenzoat 3-O-metiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + 3,4-dihidroksi-5-sve-trans-poliprenilbenzoat S-adenozil-L-homocistein + 3-metoksi-4-hidroksi-5-sve-trans-poliprenilbenzoat
Ovaj enzim učestvuje u biosintezi ubihinona. Ubihinoni iz različitih organizama imaju različiti broj prenilnih jedinica.
Reference[уреди | уреди извор]
- ^ Clarke, C.F., Williams, W., Teruya, J.H. (1991). „Ubiquinone biosynthesis in Saccharomyces cerevisiae. Isolation and sequence of COQ3, the 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase gene”. J. Biol. Chem. 266: 16636—16641. PMID 1885593.
- ^ Poon, W.W., Barkovich, R.J., Hsu, A.Y., Frankel, A., Lee, P.T., Shepherd, J.N., Myles, D.C. and Clarke, C.F. (1999). „Yeast and rat Coq3 and Escherichia coli UbiG polypeptides catalyze both O-methyltransferase steps in coenzyme Q biosynthesis”. J. Biol. Chem. 274: 21665—21672. PMID 10419476.
- ^ Jonassen, T. & Clarke, C.F. (2000). „Isolation and functional expression of human COQ3, a gene encoding a methyltransferase required for ubiquinone biosynthesis”. J. Biol. Chem. 275: 12381—12387. PMID 10777520.
- ^ Xing, L., Zhu, Y., Fang, P., Wang, J., Zeng, F., Li, X., Teng, M. and Li, X. (2011). „Crystallization and preliminary crystallographic studies of UbiG, an O-methyltransferase from Escherichia coli”. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 67: 727—729. PMID 21636923.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Polyprenyldihydroxybenzoate+methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
