Hlorid peroksidaza
| Hlorid peroksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.11.1.10 | ||||||||
| CAS broj | 9055-20-3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Hlorid peroksidaza (EC 1.11.1.10, hloroperoksidaza, CPO, vanadiumska haloperoksidaza) je enzim sa sistematskim imenom hlorid:vodonik-peroksid oksidoreduktaza.[1][2][3][4][5][6][7][8][9] Ovaj enzim katalizuje sledeću hemijsku reakciju
- RH + hlorid + H2O2 RCl + 2 H2O
Ovaj enzim deluje na niz organskih molekula, formirajući stablne C-Cl veze. On takođe oksiduje bromid i jodid. Enzimi ovog tipa su bilo hem-tiolatni proteini, ili sadrže vanadat.
Reference[уреди | уреди извор]
- ^ Morris, D.R. & Hager, L.P. (1966). „Chloroperoxidase. I. Isolation and properties of the crystalline glycoprotein”. J. Biol. Chem. 241: 1763—1768. PMID 5949836.
- ^ Hager, L.P., Hollenberg, P.F., Rand-Meir, T., Chiang, R. and Doubek, D.L. (1975). „Chemistry of peroxidase intermediates”. Ann. N.Y. Acad. Sci. 244: 80—93. PMID 1056179.
- ^ Theiler, R., Cook, J.C., Hager, L.P. and Siuda, J.F. (1978). „Halohydrocarbon synthesis by homoperoxidase”. Science. 202: 1094—1096.
- ^ Sundaramoorthy, M., Terner, J. and Poulos, T.L. (1995). „The crystal structure of chloroperoxidase: a heme peroxidase—cytochrome P450 functional hybrid”. Structure. 3: 1367—1377. PMID 8747463.
- ^ ten Brink, H.B., Tuynman, A., Dekker, H.L., Hemrika, W., Izumi, Y., Oshiro, T., Schoemaker, H.E. and Wever, R. (1998). „Enantioselective sulfoxidation catalyzed by vanadium haloperoxidases”. Inorg. Chem. 37: 6780—6784. PMID 11670813.
- ^ ten Brink, H.B., Dekker, H.L., Schoemaker, H.E. and Wever, R. (2000). „Oxidation reactions catalyzed by vanadium chloroperoxidase from Curvularia inaequalis”. J. Inorg. Biochem. 80: 91—98. PMID 10885468.
- ^ Manoj, K.M. (2006). „Chlorinations catalyzed by chloroperoxidase occur via diffusible intermediate(s) and the reaction components play multiple roles in the overall process”. Biochim. Biophys. Acta. 1764: 1325—1339. PMID 16870515.
- ^ Kuhnel, K., Blankenfeldt, W., Terner, J. and Schlichting, I. (2006). „Crystal structures of chloroperoxidase with its bound substrates and complexed with formate, acetate, and nitrate”. J. Biol. Chem. 281: 23990—23998. PMID 16790441.
- ^ Manoj, K.M. & Hager, L.P. (2008). „Chloroperoxidase, a janus enzyme”. Biochemistry. 47: 2997—3003. PMID 18220360.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Chloride+peroxidase на US National Library of Medicine Medical Subject Headings (MeSH)
