Izohinolin 1-oksidoreduktaza
| Izohinolin 1-oksidoreduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.99.16 | ||||||||
| CAS broj | 155948-73-5 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Izohinolin 1-oksidoreduktaza (EC 1.3.99.16, izohinolinska 1-oksidoreduktaza) je enzim sa sistematskim imenom izohinolin:akceptor 1-oksidoreduktaza (hidroksilacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- izohinolin + akceptor +H2O izohinolin-1(2H)-on + redukovani akceptor
Ovaj enzim iz Pseudomonas diminuta je specifičan za N-heterociklične supstrate, uključujući izohinolin, izohinolin-5-ol, ftalazin i hinazolin. Elektronski akceptori su 1,2-benzohinon, citohrom c, fericijanid, jodonitrotetrazolijum hlorid, nitroplavo tetrazolijum, Meldola plavo i fenazin metosulfat.
Reference[уреди | уреди извор]
- ^ Lehmann, M., Tshisuaka, B., Fetzner, S., Roger, P. and Lingens, F. (1994). „Purification and characterization of isoquinoline 1-oxidoreductase from Pseudomonas diminuta 7, a novel molybdenum-containing hydroxylase”. J. Biol. Chem. 269: 11254—11260. PMID 8157655.
- ^ Lehmann, M., Tshisuaka, B., Fetzner, S. and Lingens, F. (1995). „Molecular cloning of the isoquinoline 1-oxidoreductase genes from Pseudomonas diminuta 7, structural analysis of iorA and iorB, and sequence comparisons with other molybdenum-containing hydroxylases”. J. Biol. Chem. 270: 14420—14429. PMID 7782304.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Isoquinoline+1-oxidoreductase на US National Library of Medicine Medical Subject Headings (MeSH)
