Krotonil-KoA karboksilaza/reduktaza
| Krotonil-KoA karboksilaza/reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Krotonil-KoA karboksilaza/reduktaza tetramer, Streptomyces sp. NRRL 2288 | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.3.1.85 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Krotonil-KoA karboksilaza/reduktaza (EC 1.3.1.85, CCR, krotonil-KoA reduktaza (karboksilating)) je enzim sa sistematskim imenom (2S)-etilmalonil-KoA:NADP+ oksidoreduktaza (dekarboksilacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (2S)-etilmalonil-KoA + NADP+ (E)-but-2-enoil-KoA + CO2 + NADPH + H+
Ova reakcija je katalizovana u reverznom smeru. Enzim, izolovan iz bakterije Rhodobacter sphaeroides, katalizuje (E)-but-2-enoil-KoA-zavisnu oksidaciju NADPH u prisustvu CO2.
Reference[уреди | уреди извор]
- ^ Erb, T.J., Berg, I.A., Brecht, V., Muller, M., Fuchs, G. and Alber, B.E. (2007). „Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway”. Proc. Natl. Acad. Sci. USA. 104: 10631—10636. PMID 17548827.
- ^ Erb, T.J., Brecht, V., Fuchs, G., Muller, M. and Alber, B.E. (2009). „Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase”. Proc. Natl. Acad. Sci. USA. 106: 8871—8876. PMID 19458256.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Crotonyl-CoA+carboxylase/reductase на US National Library of Medicine Medical Subject Headings (MeSH)
