Linoleat 10R-lipoksigenaza
| Linoleat 10R-lipoksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.13.11.62 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Linoleat 10R-lipoksigenaza (EC 1.13.11.62, 10R-DOX, (10R)-dioksigenaza, 10R-dioksigenaza) je enzim sa sistematskim imenom linoleat:kiseonik (10R)-oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- linoleat + O2 (8E,10R,12Z)-10-hidroperoksi-8,12-oktadekadienoat
Ovaj enzim učestvuje u biosintezi oksilipina, koji utiče na sporulaciju, razviće i patogenost Aspergillus sp.
Reference[уреди | уреди извор]
- ^ Garscha, U. & Oliw, E.H. (2009). „Leucine/valine residues direct oxygenation of linoleic acid by (10R)- and (8R)-dioxygenases: expression and site-directed mutagenesis of (10R)-dioxygenase with epoxyalcohol synthase activity”. J. Biol. Chem. 284: 13755—13765. PMID 19289462.
- ^ Jerneren, F., Garscha, U., Hoffmann, I., Hamberg, M. and Oliw, E.H. (2010). „Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus”. Biochim. Biophys. Acta. 1801: 503—507. PMID 20045744.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Linoleate+10R-lipoxygenase на US National Library of Medicine Medical Subject Headings (MeSH)
