Molibdopterin sintaza
| Molibdopterin sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.8.1.12 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Molibdopterin sintaza (EC 2.8.1.12, MPT sintaza) je enzim sa sistematskim imenom tiokarboksilisana molibdopterin sintaza:ciklična piranopterin monofosfat sumportransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- ciklični piranopterin monofosfat + 2 [molibdopterin-sintaza sumpor-nosilac protein]-Gly-NH-CH2-C(O)SH +H2O molibdopterin + 2 molibdopterin-sintaza sumpor-nosilac protein
Ovaj enzim katalizuje sintezu molibdopterina iz cikličnog piranopterin monofosfata.
Reference[уреди | уреди извор]
- ^ Daniels, J.N., Wuebbens, M.M., Rajagopalan, K.V. and Schindelin, H. (2008). „Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency”. Biochemistry. 47: 615—626. PMID 18092812.
- ^ Wuebbens, M.M. & Rajagopalan, K.V. (2003). „Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis”. J. Biol. Chem. 278: 14523—14532. PMID 12571226.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Molybdopterin+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
