Protein fosfatazna metilsteraze-1
| Protein fosfatazna metilsteraze-1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.1.89 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Protein fosfatazna metilsteraze-1 (EC 3.1.1.89, PME-1, PPME1) je enzim sa sistematskim imenom (fosfataza 2A protein)-leucin estar acilhidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- [fosfataza 2A protein]-leucin metil estar + H2O [fosfataza 2A protein]-leucin + metanol
Ovaj enzim je ključni regulator proteinske fosfataza 2A.
Reference[уреди | уреди извор]
- ^ Ogris, E., Du, X., Nelson, K.C., Mak, E.K., Yu, X.X., Lane, W.S. and Pallas, D.C. (1999). „A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A”. J. Biol. Chem. 274: 14382—14391. PMID 10318862.
- ^ Xing, Y., Li, Z., Chen, Y., Stock, J.B., Jeffrey, P.D. and Shi, Y. (2008). „Structural mechanism of demethylation and inactivation of protein phosphatase 2A”. Cell. 133: 154—163. PMID 18394995.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Protein+phosphatase+methylesterase-1 на US National Library of Medicine Medical Subject Headings (MeSH)
