Salutaridinol 7-O-acetiltransferaza
| Salutaridinol 7-O-acetiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.150 | ||||||||
| CAS broj | 156859-13-1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Salutaridinol 7-O-acetiltransferaza (EC 2.3.1.150) je enzim sa sistematskim imenom acetil-KoA:salutaridinol 7-O-acetiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- acetil-KoA + salutaridinol KoA + 7-O-acetilsalutaridinol
Ovaj enzim je prisutan u maku, Papaver somniferum. Pri pH 8-9 produkt, 7-O-acetilsalutaridinol, spontano prelazi u 4->5 oksid uglavnom putem alilne eliminacije čime se formira morfinski prekurzor tebain.
Reference[уреди | уреди извор]
- ^ Lenz, R., Zenk, M.H. (1994). „Closure of the oxide bridge in morphine biosynthesis”. Tetrahedron Lett. 35: 3897—3900.
- ^ Lenz, R., Zenk, M.H. (1995). „Acetyl-CoA:salutaridinol 7-O-acetyltransferase from Papaver somniferum plant cell cultures. The enzyme catalyzing the formation of thebaine in morphine biosynthesis”. J. Biol. Chem. 270: 31091—31096. PMID 8537369.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Salutaridinol+7-O-acetyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
