Sekoizolaricirezinol dehidrogenaza
| Sekoizolaricirezinol dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.331 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Sekoizolaricirezinol dehidrogenaza (EC 1.1.1.331, sekoizolaricirezinolna dehidrogenaza) je enzim sa sistematskim imenom (-)-sekoizolaricirezinol:NAD+ oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (-)-sekoizolaricirezinol + 2 NAD+ (-)-matairezinol + 2 NADH + 2 H+
Ovaj enzim je izolovan iz biljki Forsythia intermedia i Podophyllum peltatum. In vitro se formira intermedijerni laktol.
Reference[уреди | уреди извор]
- ^ Xia, Z.Q., Costa, M.A., Pelissier, H.C., Davin, L.B. and Lewis, N.G. (2001). „Secoisolariciresinol dehydrogenase purification, cloning, and functional expression. Implications for human health protection”. J. Biol. Chem. 276: 12614—12623. PMID 11278426.
- ^ Youn, B., Moinuddin, S.G., Davin, L.B., Lewis, N.G. and Kang, C. (2005). „Crystal structures of apo-form and binary/ternary complexes of Podophyllum secoisolariciresinol dehydrogenase, an enzyme involved in formation of health-protecting and plant defense lignans”. J. Biol. Chem. 280: 12917—12926. PMID 15653677.
- ^ Moinuddin, S.G., Youn, B., Bedgar, D.L., Costa, M.A., Helms, G.L., Kang, C., Davin, L.B. and Lewis, N.G. (2006). „Secoisolariciresinol dehydrogenase: mode of catalysis and stereospecificity of hydride transfer in Podophyllum peltatum”. Org. Biomol. Chem. 4: 808—816. PMID 16493463.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Secoisolariciresinol+dehydrogenase на US National Library of Medicine Medical Subject Headings (MeSH)
