Sfinganin C4-monooksigenaza
| Sfinganin C4-monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.169 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Sfinganin C4-monooksigenaza (EC 1.14.13.169, sfingolipidna C4-hidroksilaza, SUR2 (gen), SBH1 (gen), SBH2 (gen)) je enzim sa sistematskim imenom sfinganin,NADPH:kiseonik oksidoreduktaza (C4-hidroksilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- sfinganin + NADPH + H+ + O2 fitosfingozin + NADP+ + H2O
Ovaj enzim učestvuje u biosintezi sfingolipida kod kvasca i biljki.
Reference[уреди | уреди извор]
- ^ Haak, D., Gable, K., Beeler, T. and Dunn, T. (1997). „Hydroxylation of Saccharomyces cerevisiae ceramides requires Sur2p and Scs7p”. J. Biol. Chem. 272: 29704—29710. PMID 9368039.
- ^ Grilley, M.M., Stock, S.D., Dickson, R.C., Lester, R.L. and Takemoto, J.Y. (1998). „Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiae”. J. Biol. Chem. 273: 11062—11068. PMID 9556590.
- ^ Sperling, P., Ternes, P., Moll, H., Franke, S., Zahringer, U. and Heinz, E. (2001). „Functional characterization of sphingolipid C4-hydroxylase genes from Arabidopsis thaliana”. FEBS Lett. 494: 90—94. PMID 11297741.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Sphinganine+C4-monooxygenase на US National Library of Medicine Medical Subject Headings (MeSH)
