TRNK (pseudouridin54-N1)-metiltransferaza
| TRNK (pseudouridin54-N1)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.257 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
TRNK (pseudouridin54-N1)-metiltransferaza (EC 2.1.1.257, TrmY, m1Psi metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:tRNK (pseudouridin54-N1)-metiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + pseudouridin54 u tRNK S-adenozil-L-homocistein + N1-metilpseudouridin54 u tRNK
Ovaj arhejski enzim je specifično metiliše pseudouridin u poziciji 54.
Reference[уреди | уреди извор]
- ^ Chen, H.Y. & Yuan, Y.A. (2010). „Crystal structure of Mj1640/DUF358 protein reveals a putative SPOUT-class RNA methyltransferase”. J. Mol. Cell. Biol. 2: 366—374. PMID 21098051.
- ^ Wurm, J.P., Griese, M., Bahr, U., Held, M., Heckel, A., Karas, M., Soppa, J. and Wohnert, J. (2012). „Identification of the enzyme responsible for N1-methylation of pseudouridine 54 in archaeal tRNAs”. RNA. 18: 412—420. PMID 22274954.
- ^ Chatterjee, K., Blaby, I.K., Thiaville, P.C., Majumder, M., Grosjean, H., Yuan, Y.A., Gupta, R. and de Crecy-Lagard, V. (2012). „The archaeal COG1901/DUF358 SPOUT-methyltransferase members, together with pseudouridine synthase Pus10, catalyze the formation of 1-methylpseudouridine at position 54 of tRNA”. RNA. 18: 421—433. PMID 22274953.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- TRNA+(pseudouridine54-N1)-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
