Taksan 13a-hidroksilaza
| Taksan 13a-hidroksilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.77 | ||||||||
| CAS broj | 399030-58-1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Taksan 13a-hidroksilaza (EC 1.14.13.77, taksanska 13a-hidroksilaza) je enzim sa sistematskim imenom taksa-4(20),11-dien-5alfa-ol,NADPH:kiseonik oksidoreduktaza (13alfa-hidroksilacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- taksa-4(20),11-dien-5alfa-ol + NADPH + H+ + O2 taksa-4(20),11-dien-5alfa,13alfa-diol + NADP+ + H2O
Ovaj mikrozomalni citohrom-P450-zavisni enzim učestvuje u biosinteza diterpenoidnog antineoplastičnog leka taksola (paklitaksela).
Reference[уреди | уреди извор]
- ^ Wheeler, A.L., Long, R.M., Ketchum, R.E., Rithner, C.D., Williams, R.M. and Croteau, R. (2001). „Taxol biosynthesis: differential transformations of taxadien-5α-ol and its acetate ester by cytochrome P450 hydroxylases from Taxus suspension cells”. Arch. Biochem. Biophys. 390: 265—78. PMID 11396929.
- ^ Jennewein, S., Rithner, C.D., Williams, R.M. and Croteau, R.B. (2001). „Taxol biosynthesis: taxane 13 α-hydroxylase is a cytochrome P450-dependent monooxygenase”. Proc. Natl. Acad. Sci. USA. 98: 13595—13560. PMID 11707604.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Taxane+13alpha-hydroxylase на US National Library of Medicine Medical Subject Headings (MeSH)
