Trans-heksapreniltranstransferaza
| Trans-heksapreniltranstransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.30 | ||||||||
| CAS broj | 74506-59-5 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Trans-heksapreniltranstransferaza (EC 2.5.1.30, sve-trans-heptaprenil-difosfatna sintaza, heptaprenil pirofosfatna sintaza, heptaprenil pirofosfatna sintetaza, HepPP sintaza, HepPS, heptaprenilpirofosfatna sintetaza) je enzim sa sistematskim imenom (2E,6E)-farnezil-difosfat:izopentenil-difosfat farneziltranstransferaza (dodaje 4 izopentenilne jedinice).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (2E,6E)-farnezil difosfat + 4 izopentenil difosfat 4 difosfat + sve-trans-heptaprenil difosfat
Ovaj enzim katalizuje reakcije kondenzacije reakcije kojima se formira sve-trans-heptaprenilni difosfat, izoprenoidni bočni lanac ubihinona-7 i menahinona-7.
Reference[уреди | уреди извор]
- ^ Takahashi, I., Ogura, K. and Seto, S. (1980). „Heptaprenyl pyrophosphate synthetase from Bacillus subtilis”. J. Biol. Chem. 255: 4539—4543. PMID 6768722.
- ^ Zhang, Y.W., Koyama, T., Marecak, D.M., Prestwich, G.D., Maki, Y. and Ogura, K. (1998). „Two subunits of heptaprenyl diphosphate synthase of Bacillus subtilis form a catalytically active complex”. Biochemistry. 37: 13411—13420. PMID 9748348.
- ^ Zhang, Y.W., Li, X.Y., Sugawara, H. and Koyama, T. (1999). „Site-directed mutagenesis of the conserved residues in component I of Bacillus subtilis heptaprenyl diphosphate synthase”. Biochemistry. 38: 14638—14643. PMID 10545188.
- ^ Suzuki, T., Zhang, Y.W., Koyama, T., Sasaki, D.Y. and Kurihara, K. (2006). „Direct observation of substrate-enzyme complexation by surface forces measurement”. J. Am. Chem. Soc. 128: 15209—15214. PMID 17117872.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Heptaprenyl+diphosphate+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
