Trimetilamin-N-oksid reduktaza (citohrom c)
| Trimetilamin-N-oksid reduktaza (citohrom c) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.7.2.3 | ||||||||
| CAS broj | 37256-34-1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Trimetilamin-N-oksid reduktaza (citohrom c) (EC 1.7.2.3, TMAO reduktaza, TOR) je enzim sa sistematskim imenom trimetilamin:citohrom c oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- trimetilamin + 2 (fericitohrom c)-podjedinica + H2O trimetilamin N-oksid + 2 (ferrocitohrom c)-podjedinica + 2 H+
Citohrom c prisutan kod fotosintetičkih bakterija je pentahemni protein. On sadrži bis(molibdopterinski guaninski dinukleotid)molibdenumski kofaktor.
Reference[уреди | уреди извор]
- ^ Arata, H., Shimizu, M. and Takamiya, K. (1992). „Purification and properties of trimethylamine N-oxide reductase from aerobic photosynthetic bacterium Roseobacter denitrificans”. J. Biochem. (Tokyo). 112: 470—475. PMID 1337081.
- ^ Knablein, J., Dobbek, H., Ehlert, S. and Schneider, F. (1997). „Isolation, cloning, sequence analysis and X-ray structure of dimethyl sulfoxide trimethylamine N-oxide reductase from Rhodobacter capsulatus”. Biol. Chem. 378: 293—302. PMID 9165084.
- ^ Czjzek, M., Dos Santos, J.P., Pommier, J., Giordano, G., Méjean, V. and Haser, R. (1998). „Crystal structure of oxidized trimethylamine N-oxide reductase from Shewanella massilia at 2.5 Å resolution”. J. Mol. Biol. 284: 435—447. PMID 9813128.
- ^ Gon, S., Giudici-Orticoni, M.T., Mejean, V. and Iobbi-Nivol, C. (2001). „Electron transfer and binding of the c-type cytochrome TorC to the trimethylamine N-oxide reductase in Escherichia coli”. J. Biol. Chem. 276: 11545—11551. PMID 11056172.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Trimethylamine-N-oxide+reductase+(cytochrome+c) на US National Library of Medicine Medical Subject Headings (MeSH)
