UDP-N-acetilglukozaminska 4,6-dehidrataza (inverzija konfiguracije)
| UDP-N-acetilglukozaminska 4,6-dehidrataza (inverzija konfiguracije) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.115 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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UDP-N-acetilglukozaminska 4,6-dehidrataza (inverzija konfiguracije) (EC 4.2.1.115, FlaA1, UDP-N-acetilglukozamin 5-invertujuća 4,6-dehidrataza, PseB, UDP-N-acetilglukozaminska hidrolijaza (vrši inverziju, formira UDP-2-acetamido-2,6-didezoksi-beta-L-arabino-heks-4-uloza)) je enzim sa sistematskim imenom UDP-N-acetil-alfa-D-glukozamin hidrolijaza (inverzija, formira UDP-2-acetamido-2,6-didezoksi-beta-L-arabino-heks-4-uloza).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-N-acetil-alfa-D-glukozamin UDP-2-acetamido-2,6-didezoksi-beta-L-arabino-heks-4-uloza + H2O
Ovaj enzim dasrži NADP+ kao kofaktor.
Reference[уреди | уреди извор]
- ^ Ishiyama, N., Creuzenet, C., Miller, W.L., Demendi, M., Anderson, E.M., Harauz, G., Lam, J.S. and Berghuis, A.M. (2006). „Structural studies of FlaA1 from Helicobacter pylori reveal the mechanism for inverting 4,6-dehydratase activity”. J. Biol. Chem. 281: 24489—24495. PMID 16651261.
- ^ Schirm, M., Soo, E.C., Aubry, A.J., Austin, J., Thibault, P. and Logan, S.M. (2003). „Structural, genetic and functional characterization of the flagellin glycosylation process in Helicobacter pylori”. Mol. Microbiol. 48: 1579—1592. PMID 12791140.
- ^ Schoenhofen, I.C., McNally, D.J., Brisson, J.R. and Logan, S.M. (2006). „Elucidation of the CMP-pseudaminic acid pathway in Helicobacter pylori: synthesis from UDP-N-acetylglucosamine by a single enzymatic reaction”. Glycobiology. 16: 8C—14C. PMID 16751642.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- UDP-N-acetylglucosamine+4,6-dehydratase+(configuration-inverting) на US National Library of Medicine Medical Subject Headings (MeSH)
