Retinalni G protein spregnuti receptor — разлика између измена
Садржај обрисан Садржај додат
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==Literatura== |
==Literatura== |
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==Dodatna literatura== |
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*{{cite journal | author=Jiang M, Shen D, Tao L, ''et al.'' |title=Alternative splicing in human retinal mRNA transcripts of an opsin-related protein. |journal=Exp. Eye Res. |volume=60 |issue= 4 |pages= 401–6 |year= 1995 |pmid= 7789419 |doi=10.1016/S0014-4835(05)80096-X }} |
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*{{cite journal | author=Shen D, Jiang M, Hao W, ''et al.'' |title=A human opsin-related gene that encodes a retinaldehyde-binding protein. |journal=Biochemistry |volume=33 |issue= 44 |pages= 13117–25 |year= 1994 |pmid= 7947717 |doi=10.1021/bi00248a022 }} |
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*{{cite journal | author=Morimura H, Saindelle-Ribeaudeau F, Berson EL, Dryja TP |title=Mutations in RGR, encoding a light-sensitive opsin homologue, in patients with retinitis pigmentosa. |journal=Nat. Genet. |volume=23 |issue= 4 |pages= 393–4 |year= 1999 |pmid= 10581022 |doi= 10.1038/70496 }} |
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*{{cite journal | author=Chen P, Lee TD, Fong HK |title=Interaction of 11-cis-retinol dehydrogenase with the chromophore of retinal g protein-coupled receptor opsin. |journal=J. Biol. Chem. |volume=276 |issue= 24 |pages= 21098–104 |year= 2001 |pmid= 11274198 |doi= 10.1074/jbc.M010441200 }} |
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*{{cite journal | author=Yang M, Fong HK |title=Synthesis of the all-trans-retinal chromophore of retinal G protein-coupled receptor opsin in cultured pigment epithelial cells. |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3318–24 |year= 2002 |pmid= 11723126 |doi= 10.1074/jbc.M108946200 }} |
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*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} |
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*{{cite journal | author=Bellingham J, Wells DJ, Foster RG |title=In silico characterisation and chromosomal localisation of human RRH (peropsin)--implications for opsin evolution. |journal=BMC Genomics |volume=4 |issue= 1 |pages= 3 |year= 2003 |pmid= 12542842 |doi=10.1186/1471-2164-4-3 | pmc=149353 }} |
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*{{cite journal | author=Tarttelin EE, Bellingham J, Bibb LC, ''et al.'' |title=Expression of opsin genes early in ocular development of humans and mice. |journal=Exp. Eye Res. |volume=76 |issue= 3 |pages= 393–6 |year= 2003 |pmid= 12573668 |doi=10.1016/S0014-4835(02)00300-7 }} |
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*{{cite journal | author=Bernal S, Calaf M, Garcia-Hoyos M, ''et al.'' |title=Study of the involvement of the RGR, CRPB1, and CRB1 genes in the pathogenesis of autosomal recessive retinitis pigmentosa. |journal=J. Med. Genet. |volume=40 |issue= 7 |pages= e89 |year= 2003 |pmid= 12843338 |doi=10.1136/jmg.40.7.e89 | pmc=1735523 }} |
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*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} |
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*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }} |
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*{{cite journal | author=Zhu L, Imanishi Y, Filipek S, ''et al.'' |title=Autosomal recessive retinitis pigmentosa and E150K mutation in the opsin gene. |journal=J. Biol. Chem. |volume=281 |issue= 31 |pages= 22289–98 |year= 2006 |pmid= 16737970 |doi= 10.1074/jbc.M602664200 | pmc=1618956 }} |
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*{{cite journal | author=Lin MY, Kochounian H, Moore RE, ''et al.'' |title=Deposition of exon-skipping splice isoform of human retinal G protein-coupled receptor from retinal pigment epithelium into Bruch's membrane. |journal=Mol. Vis. |volume=13 |issue= |pages= 1203–14 |year= 2007 |pmid= 17679941 |doi= }} |
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Верзија на датум 2. април 2011. у 05:45
| Retinalni G protein spregnuti receptor | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | RGR; | ||||||||||
| Vanjski ID | OMIM: 600342 MGI: 1929473 HomoloGene: 37709 GeneCards: RGR Gene | ||||||||||
| |||||||||||
| Pregled RNK izražavanja | |||||||||||
 | |||||||||||
| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 5995 | 57811 | |||||||||
| Ensembl | ENSG00000148604 | ENSMUSG00000021804 | |||||||||
| UniProt | P47804 | Q3UEX9 | |||||||||
| RefSeq (mRNA) | NM_001012720 | NM_021340 | |||||||||
| RefSeq (protein) | NP_001012738 | NP_067315 | |||||||||
| Lokacija (UCSC) |
Chr 10: 85.99 - 86.01 Mb |
Chr 14: 35.95 - 35.96 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Retinalni G protein spregnuti receptor je protein koji je kod čoveka kodiran RGR genom.[1][2]
{{PBB_Summary | section_title = | summary_text = Defekti ovog gena su uzrok retinitis pigmentose. Oni mogu da se ispolje kao autosomalna recesivna ili dominantna retinitis pigmentosa (arRP i adRP, respektivno). Ovaj gen je član familije rodopsinu-sličnih receptora GPCR. Poput drugih opsina koji vezuju retinaldehid, on sadrži konzervirani lizin u svom sedmom transmembranskom domenu. Za ovaj protein se smatra da dejstvuje kao fotoizomeraza koja katalizuje konverziju sve-trans-retinala u 11-cis-retinal, slično retinohromu kod bezkičmenjaka. Reverzna izomerizacija rodopsina se odvija u retinalnim fotoreceptorskim ćelijama. Ovaj protein je ekskluzivno izražen u tkivima koja su susedna retinalnim fotoreceptorskim ćelijama i retinalnom pigmentnom epitelu. Alternativno splajsovanje rezultira u višestrukim transkriptnim varijantama koje kodiraju različite isoforme.[2]
Interakcije
Za retinalni G protein spregnuti receptor je bilo pokazano da interaguje sa KIAA1279.[3]
Literatura
- ^ Chen XN, Korenberg JR, Jiang M, Shen D, Fong HK (1996). „Localization of the human RGR opsin gene to chromosome 10q23”. Hum Genet. 97 (6): 720—2. PMID 8641686. doi:10.1007/BF02346179. Непознати параметар
|month=игнорисан (помоћ) - ^ а б „Entrez Gene: RGR retinal G protein coupled receptor”.
- ^ Rual, Jean-François (2005). „Towards a proteome-scale map of the human protein-protein interaction network”. Nature. England. 437 (7062): 1173—8. PMID 16189514. doi:10.1038/nature04209. Непознати параметар
|month=игнорисан (помоћ); Непознати параметар|coauthors=игнорисан [|author=се препоручује] (помоћ); Проверите вредност парамет(а)ра за датум:|date=(помоћ)
Dodatna literatura
- Jiang M, Shen D, Tao L; et al. (1995). „Alternative splicing in human retinal mRNA transcripts of an opsin-related protein.”. Exp. Eye Res. 60 (4): 401—6. PMID 7789419. doi:10.1016/S0014-4835(05)80096-X.
- Shen D, Jiang M, Hao W; et al. (1994). „A human opsin-related gene that encodes a retinaldehyde-binding protein.”. Biochemistry. 33 (44): 13117—25. PMID 7947717. doi:10.1021/bi00248a022.
- Morimura H, Saindelle-Ribeaudeau F, Berson EL, Dryja TP (1999). „Mutations in RGR, encoding a light-sensitive opsin homologue, in patients with retinitis pigmentosa.”. Nat. Genet. 23 (4): 393—4. PMID 10581022. doi:10.1038/70496.
- Chen P, Lee TD, Fong HK (2001). „Interaction of 11-cis-retinol dehydrogenase with the chromophore of retinal g protein-coupled receptor opsin.”. J. Biol. Chem. 276 (24): 21098—104. PMID 11274198. doi:10.1074/jbc.M010441200.
- Yang M, Fong HK (2002). „Synthesis of the all-trans-retinal chromophore of retinal G protein-coupled receptor opsin in cultured pigment epithelial cells.”. J. Biol. Chem. 277 (5): 3318—24. PMID 11723126. doi:10.1074/jbc.M108946200.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899. - Bellingham J, Wells DJ, Foster RG (2003). „In silico characterisation and chromosomal localisation of human RRH (peropsin)--implications for opsin evolution.”. BMC Genomics. 4 (1): 3. PMC 149353 . PMID 12542842. doi:10.1186/1471-2164-4-3.
- Tarttelin EE, Bellingham J, Bibb LC; et al. (2003). „Expression of opsin genes early in ocular development of humans and mice.”. Exp. Eye Res. 76 (3): 393—6. PMID 12573668. doi:10.1016/S0014-4835(02)00300-7.
- Bernal S, Calaf M, Garcia-Hoyos M; et al. (2003). „Study of the involvement of the RGR, CRPB1, and CRB1 genes in the pathogenesis of autosomal recessive retinitis pigmentosa.”. J. Med. Genet. 40 (7): e89. PMC 1735523 . PMID 12843338. doi:10.1136/jmg.40.7.e89.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Rual JF, Venkatesan K, Hao T; et al. (2005). „Towards a proteome-scale map of the human protein-protein interaction network.”. Nature. 437 (7062): 1173—8. PMID 16189514. doi:10.1038/nature04209.
- Zhu L, Imanishi Y, Filipek S; et al. (2006). „Autosomal recessive retinitis pigmentosa and E150K mutation in the opsin gene.”. J. Biol. Chem. 281 (31): 22289—98. PMC 1618956 . PMID 16737970. doi:10.1074/jbc.M602664200.
- Lin MY, Kochounian H, Moore RE; et al. (2007). „Deposition of exon-skipping splice isoform of human retinal G protein-coupled receptor from retinal pigment epithelium into Bruch's membrane.”. Mol. Vis. 13: 1203—14. PMID 17679941.
