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Нова страница: {{PBB|geneid=2740}} '''Receptor glukagonu sličnog peptida 1''' (-{''GLP1R''}-) je ljudski gen koji se nalazi na hromozomu 6.<re…
 
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==Reference==
==Reference==
{{Reflist|2}}
{{Reflist|2}}

==Literatura==
{{Refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=van Eyll B, Lankat-Buttgereit B, Bode HP, ''et al.'' |title=Signal transduction of the GLP-1-receptor cloned from a human insulinoma |journal=FEBS Lett. |volume=348 |issue= 1 |pages= 7–13 |year= 1994 |pmid= 7517895 |doi=10.1016/0014-5793(94)00553-2 }}
*{{cite journal | author=Gromada J, Rorsman P, Dissing S, Wulff BS |title=Stimulation of cloned human glucagon-like peptide 1 receptor expressed in HEK 293 cells induces cAMP-dependent activation of calcium-induced calcium release |journal=FEBS Lett. |volume=373 |issue= 2 |pages= 182–6 |year= 1995 |pmid= 7589461 |doi=10.1016/0014-5793(95)01070-U }}
*{{cite journal | author=Wei Y, Mojsov S |title=Tissue-specific expression of the human receptor for glucagon-like peptide-I: brain, heart and pancreatic forms have the same deduced amino acid sequences |journal=FEBS Lett. |volume=358 |issue= 3 |pages= 219–24 |year= 1995 |pmid= 7843404 |doi=10.1016/0014-5793(94)01430-9 }}
*{{cite journal | author=Lankat-Buttgereit B, Göke R, Stöckmann F, ''et al.'' |title=Detection of the human glucagon-like peptide 1(7-36) amide receptor on insulinoma-derived cell membranes |journal=Digestion |volume=55 |issue= 1 |pages= 29–33 |year= 1994 |pmid= 8112494 |doi=10.1159/000201119 }}
*{{cite journal | author=Graziano MP, Hey PJ, Borkowski D, ''et al.'' |title=Cloning and functional expression of a human glucagon-like peptide-1 receptor |journal=Biochem. Biophys. Res. Commun. |volume=196 |issue= 1 |pages= 141–6 |year= 1993 |pmid= 8216285 |doi= 10.1006/bbrc.1993.2226 }}
*{{cite journal | author=Stoffel M, Espinosa R, Le Beau MM, Bell GI |title=Human glucagon-like peptide-1 receptor gene. Localization to chromosome band 6p21 by fluorescence in situ hybridization and linkage of a highly polymorphic simple tandem repeat DNA polymorphism to other markers on chromosome 6 |journal=Diabetes |volume=42 |issue= 8 |pages= 1215–8 |year= 1993 |pmid= 8392011 |doi=10.2337/diabetes.42.8.1215 }}
*{{cite journal | author=Dillon JS, Tanizawa Y, Wheeler MB, ''et al.'' |title=Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor |journal=Endocrinology |volume=133 |issue= 4 |pages= 1907–10 |year= 1993 |pmid= 8404634 |doi=10.1210/en.133.4.1907 }}
*{{cite journal | author=Thorens B, Porret A, Bühler L, ''et al.'' |title=Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor |journal=Diabetes |volume=42 |issue= 11 |pages= 1678–82 |year= 1993 |pmid= 8405712 |doi=10.2337/diabetes.42.11.1678 }}
*{{cite journal | author=Lankat-Buttgereit B, Göke B |title=Cloning and characterization of the 5' flanking sequences (promoter region) of the human GLP-1 receptor gene |journal=Peptides |volume=18 |issue= 5 |pages= 617–24 |year= 1997 |pmid= 9213353 |doi=10.1016/S0196-9781(97)00001-6 }}
*{{cite journal | author=Frimurer TM, Bywater RP |title=Structure of the integral membrane domain of the GLP1 receptor |journal=Proteins |volume=35 |issue= 4 |pages= 375–86 |year= 1999 |pmid= 10382665 |doi=10.1002/(SICI)1097-0134(19990601)35:4<375::AID-PROT1>3.0.CO;2-2 }}
*{{cite journal | author=Huypens P, Ling Z, Pipeleers D, Schuit F |title=Glucagon receptors on human islet cells contribute to glucose competence of insulin release |journal=Diabetologia |volume=43 |issue= 8 |pages= 1012–9 |year= 2001 |pmid= 10990079 |doi=10.1007/s001250051484 }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }}
*{{cite journal | author=Xiao Q, Jeng W, Wheeler MB |title=Characterization of glucagon-like peptide-1 receptor-binding determinants |journal=J. Mol. Endocrinol. |volume=25 |issue= 3 |pages= 321–35 |year= 2001 |pmid= 11116211 |doi=10.1677/jme.0.0250321 }}
*{{cite journal | author=Bazarsuren A, Grauschopf U, Wozny M, ''et al.'' |title=In vitro folding, functional characterization, and disulfide pattern of the extracellular domain of human GLP-1 receptor |journal=Biophys. Chem. |volume=96 |issue= 2-3 |pages= 305–18 |year= 2003 |pmid= 12034449 |doi=10.1016/S0301-4622(02)00023-6 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Tokuyama Y, Matsui K, Egashira T, ''et al.'' |title=Five missense mutations in glucagon-like peptide 1 receptor gene in Japanese population |journal=Diabetes Res. Clin. Pract. |volume=66 |issue= 1 |pages= 63–9 |year= 2005 |pmid= 15364163 |doi= 10.1016/j.diabres.2004.02.004 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Jorgensen R, Martini L, Schwartz TW, Elling CE |title=Characterization of glucagon-like peptide-1 receptor beta-arrestin 2 interaction: a high-affinity receptor phenotype |journal=Mol. Endocrinol. |volume=19 |issue= 3 |pages= 812–23 |year= 2005 |pmid= 15528268 |doi= 10.1210/me.2004-0312 }}
*{{cite journal | author=Mahon MJ, Shimada M |title=Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors |journal=FEBS Lett. |volume=579 |issue= 3 |pages= 803–7 |year= 2005 |pmid= 15670850 |doi= 10.1016/j.febslet.2004.12.056 }}
}}
{{Refend}}

==Vidi još==

Верзија на датум 4. август 2012. у 04:15

Receptor glukagonu sličnog peptida 1‎‎
Prikaz bazira na PDB 3C59​.
Dostupne strukture
3C59​, 3C5T​, 3IOL​
Identifikatori
Simboli GLP1R; MGC138331
Vanjski ID OMIM: 138032 MGI: 99571 HomoloGene: 1558 IUPHAR: GLP-1 GeneCards: GLP1R Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 2740 14652
Ensembl ENSG00000112164 ENSMUSG00000024027
UniProt P43220 E9Q7I1
RefSeq (mRNA) NM_002062.3 NM_021332.2
RefSeq (protein) NP_002053.3 NP_067307.2
Lokacija (UCSC) Chr 6:
39.02 - 39.06 Mb		 Chr 17:
31.04 - 31.07 Mb
PubMed pretraga [1] [2]

Receptor glukagonu sličnog peptida 1 (GLP1R) je ljudski gen koji se nalazi na hromozomu 6.[1][2] Ovaj protein je član glukogenske receptorske familije G protein spregnutih receptora.[3]

Reference

  1. ^ Thorens B (1992). „Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1”. Proc. Natl. Acad. Sci. U.S.A. 89 (18): 8641—5. PMC 49976 Слободан приступ. PMID 1326760. doi:10.1073/pnas.89.18.8641.  Непознати параметар |month= игнорисан (помоћ)
  2. ^ Dillon JS, Tanizawa Y, Wheeler MB, Leng XH, Ligon BB, Rabin DU, Yoo-Warren H, Permutt MA, Boyd AE 3rd (1993). „Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor”. Endocrinology. 133 (4): 1907—10. PMID 8404634. doi:10.1210/en.133.4.1907.  Непознати параметар |month= игнорисан (помоћ)
  3. ^ Brubaker PL, Drucker DJ (2002). „Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors” (PDF). Recept. Channels. 8 (3-4): 179—88. PMID 12529935. doi:10.1080/10606820213687. Приступљено 2008-07-14. 

Literatura

  • van Eyll B, Lankat-Buttgereit B, Bode HP; et al. (1994). „Signal transduction of the GLP-1-receptor cloned from a human insulinoma”. FEBS Lett. 348 (1): 7—13. PMID 7517895. doi:10.1016/0014-5793(94)00553-2. 
  • Gromada J, Rorsman P, Dissing S, Wulff BS (1995). „Stimulation of cloned human glucagon-like peptide 1 receptor expressed in HEK 293 cells induces cAMP-dependent activation of calcium-induced calcium release”. FEBS Lett. 373 (2): 182—6. PMID 7589461. doi:10.1016/0014-5793(95)01070-U. 
  • Wei Y, Mojsov S (1995). „Tissue-specific expression of the human receptor for glucagon-like peptide-I: brain, heart and pancreatic forms have the same deduced amino acid sequences”. FEBS Lett. 358 (3): 219—24. PMID 7843404. doi:10.1016/0014-5793(94)01430-9. 
  • Lankat-Buttgereit B, Göke R, Stöckmann F; et al. (1994). „Detection of the human glucagon-like peptide 1(7-36) amide receptor on insulinoma-derived cell membranes”. Digestion. 55 (1): 29—33. PMID 8112494. doi:10.1159/000201119. 
  • Graziano MP, Hey PJ, Borkowski D; et al. (1993). „Cloning and functional expression of a human glucagon-like peptide-1 receptor”. Biochem. Biophys. Res. Commun. 196 (1): 141—6. PMID 8216285. doi:10.1006/bbrc.1993.2226. 
  • Stoffel M, Espinosa R, Le Beau MM, Bell GI (1993). „Human glucagon-like peptide-1 receptor gene. Localization to chromosome band 6p21 by fluorescence in situ hybridization and linkage of a highly polymorphic simple tandem repeat DNA polymorphism to other markers on chromosome 6”. Diabetes. 42 (8): 1215—8. PMID 8392011. doi:10.2337/diabetes.42.8.1215. 
  • Dillon JS, Tanizawa Y, Wheeler MB; et al. (1993). „Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor”. Endocrinology. 133 (4): 1907—10. PMID 8404634. doi:10.1210/en.133.4.1907. 
  • Thorens B, Porret A, Bühler L; et al. (1993). „Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor”. Diabetes. 42 (11): 1678—82. PMID 8405712. doi:10.2337/diabetes.42.11.1678. 
  • Lankat-Buttgereit B, Göke B (1997). „Cloning and characterization of the 5' flanking sequences (promoter region) of the human GLP-1 receptor gene”. Peptides. 18 (5): 617—24. PMID 9213353. doi:10.1016/S0196-9781(97)00001-6. 
  • Frimurer TM, Bywater RP (1999). „Structure of the integral membrane domain of the GLP1 receptor”. Proteins. 35 (4): 375—86. PMID 10382665. doi:10.1002/(SICI)1097-0134(19990601)35:4<375::AID-PROT1>3.0.CO;2-2. 
  • Huypens P, Ling Z, Pipeleers D, Schuit F (2001). „Glucagon receptors on human islet cells contribute to glucose competence of insulin release”. Diabetologia. 43 (8): 1012—9. PMID 10990079. doi:10.1007/s001250051484. 
  • Hartley JL, Temple GF, Brasch MA (2001). „DNA cloning using in vitro site-specific recombination”. Genome Res. 10 (11): 1788—95. PMC 310948 Слободан приступ. PMID 11076863. doi:10.1101/gr.143000. 
  • Xiao Q, Jeng W, Wheeler MB (2001). „Characterization of glucagon-like peptide-1 receptor-binding determinants”. J. Mol. Endocrinol. 25 (3): 321—35. PMID 11116211. doi:10.1677/jme.0.0250321. 
  • Bazarsuren A, Grauschopf U, Wozny M; et al. (2003). „In vitro folding, functional characterization, and disulfide pattern of the extracellular domain of human GLP-1 receptor”. Biophys. Chem. 96 (2-3): 305—18. PMID 12034449. doi:10.1016/S0301-4622(02)00023-6. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 Слободан приступ. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Mungall AJ, Palmer SA, Sims SK; et al. (2003). „The DNA sequence and analysis of human chromosome 6”. Nature. 425 (6960): 805—11. PMID 14574404. doi:10.1038/nature02055. 
  • Tokuyama Y, Matsui K, Egashira T; et al. (2005). „Five missense mutations in glucagon-like peptide 1 receptor gene in Japanese population”. Diabetes Res. Clin. Pract. 66 (1): 63—9. PMID 15364163. doi:10.1016/j.diabres.2004.02.004. 
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121—7. PMC 528928 Слободан приступ. PMID 15489334. doi:10.1101/gr.2596504. 
  • Jorgensen R, Martini L, Schwartz TW, Elling CE (2005). „Characterization of glucagon-like peptide-1 receptor beta-arrestin 2 interaction: a high-affinity receptor phenotype”. Mol. Endocrinol. 19 (3): 812—23. PMID 15528268. doi:10.1210/me.2004-0312. 
  • Mahon MJ, Shimada M (2005). „Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors”. FEBS Lett. 579 (3): 803—7. PMID 15670850. doi:10.1016/j.febslet.2004.12.056. 

Vidi još

Преузето из „https://sr.wikipedia.org/w/index.php?title=Receptor_glukagonu_sličnog_peptida_1&oldid=5814073”