Trifunkcioni purinski biosintetički protein adenozin-3 — разлика између измена
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| Name = Trifunkcioni purinski biosintetički protein adenozin-3 |
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| EC_number = 2.1.2.2 |
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| CAS_number = 2604945 |
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| IUBMB_EC_number = 2/1/2/2 |
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'''Trifunkcioni purinski biosintetički protein adenozin-3''' ({{EC broj-lat|2.1.2.2}}, ''2-amino--{N}--ribozilacetamid 5'-fosfatna transformilaza'', ''-{GAR}- formiltransferaza'', ''-{GAR}- transformilaza'', ''glicinamid ribonukleotidna transformilaza'', ''-{GAR}- TFaza'', ''5,10-meteniltetrahidrofolat:2-amino--{N}--ribozilacetamid ribonukleotid transformilaza'') je [[enzim]] sa sistematskim imenom ''10-formiltetrahidrofolat:5'-fosforibozilglicinamid -{N}--formiltransferaza''.<ref>{{cite journal | title = Biosynthesis of the purines. XXVI. The identification of the formyl donors of the transformylation reaction |author = Hartman, S.C. and Buchanan, J.M. |journal = J. Biol. Chem. |date = 1959 |volume = 234 |pages = 1812-1816 |pmid = 13672969}}</ref><ref>{{cite journal | title = L(-)-10-Formyltetrahydrofolate is the cofactor for glycinamide ribonucleotide transformylase from chicken liver |author = Smith, G.K., Benkovic, P.A. and Benkovic, S.J. |journal = Biochemistry |date = 1981 |volume = 20 |pages = 4034-4036 |pmid = 7284307}}</ref><ref>{{cite journal | title = Biosynthesis of the purines. XIX. 2-Amino-<em>N</em>-ribosylacetamide 5′-phosphate (glycinamide ribotide) transformylase |author = Warren, L. and Buchanan, J.M. |journal = J. Biol. Chem. |date = 1957 |volume = 229 |pages = 613-626 |pmid = 13502326}}</ref> Ovaj enzim [[Катализа|katalizuje]] sledeću [[hemijska reakcija|hemijsku reakciju]] |
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'''Trifunkcioni purinski biosintetički protein adenozin-3''' je [[enzim]] koji je kod ljudi kodiran ''GART'' [[genom]].<ref name="pmid2050105">{{cite journal | author = Gnirke A, Barnes TS, Patterson D, Schild D, Featherstone T, Olson MV | title = Cloning and in vivo expression of the human GART gene using yeast artificial chromosomes | journal = EMBO J. | volume = 10 | issue = 7 | pages = 1629–34 | year = 1991 | month = July | pmid = 2050105 | pmc = 452831 | doi = | url = | issn = }}</ref> |
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: 10-formiltetrahidrofolat + -{N}-<sup>1</sup>-(5-fosfo--{D}--ribozil)glicinamid <math>\rightleftharpoons</math> [[tetrahidrofolat]] + -{N}-<sup>2</sup>-formil--{N}-<sup>1</sup>-(5-fosfo--{D}--ribozil)glicinamid |
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Ovaj protein je trofunkcionalni polipeptid. On deluje kao [[fosforibozilamin-glicin ligaza|fosforibozilglicinamid formiltransferaza]] (EC 6.3.4.13), [[AIR sintetaza (FGAM ciklaza)|fosforibozilglicinamidna sintetaza]] (EC 6.3.3.1), [[Fosforibozilglicinamid formiltransferaza|fosforibozilaminoimidazolna sintetaza]] (EC 2.1.2.2), koji je neophodan za de novo [[purin]]sku biosintezu. |
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== Reference == |
== Reference == |
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==Literatura== |
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*{{cite journal |author=Hattori M, Fujiyama A, Taylor TD, ''et al.'' |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 }} |
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*{{cite journal |author=Banerjee D, Nandagopal K |title=Potential interaction between the GARS-AIRS-GART Gene and CP2/LBP-1c/LSF transcription factor in Down syndrome-related Alzheimer disease. |journal=Cell. Mol. Neurobiol. |volume=27 |issue= 8 |pages= 1117–26 |year= 2007 |pmid= 17902044 |doi= 10.1007/s10571-007-9217-2 }} |
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*{{cite journal |author=Dahms TE, Sainz G, Giroux EL, ''et al.'' |title=The apo and ternary complex structures of a chemotherapeutic target: human glycinamide ribonucleotide transformylase. |journal=Biochemistry |volume=44 |issue= 29 |pages= 9841–50 |year= 2005 |pmid= 16026156 |doi= 10.1021/bi050307g }} |
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*{{cite journal |author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 |pmc=1356129}} |
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*{{cite journal |author=Dagle JM, Lepp NT, Cooper ME, ''et al.'' |title=Determination of genetic predisposition to patent ductus arteriosus in preterm infants. |journal=Pediatrics |volume=123 |issue= 4 |pages= 1116–23 |year= 2009 |pmid= 19336370 |doi= 10.1542/peds.2008-0313 |pmc=2734952}} |
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*{{cite journal |author=Franke B, Vermeulen SH, Steegers-Theunissen RP, ''et al.'' |title=An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1). |journal=Birth Defects Res. Part A Clin. Mol. Teratol. |volume=85 |issue= 3 |pages= 216–26 |year= 2009 |pmid= 19161160 |doi= 10.1002/bdra.20556 }} |
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*{{cite journal |author=Barbe L, Lundberg E, Oksvold P, ''et al.'' |title=Toward a confocal subcellular atlas of the human proteome. |journal=Mol. Cell Proteomics |volume=7 |issue= 3 |pages= 499–508 |year= 2008 |pmid= 18029348 |doi= 10.1074/mcp.M700325-MCP200 }} |
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*{{cite journal |author=Zhang Y, Desharnais J, Marsilje TH, ''et al.'' |title=Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid. |journal=Biochemistry |volume=42 |issue= 20 |pages= 6043–56 |year= 2003 |pmid= 12755606 |doi= 10.1021/bi034219c }} |
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*{{cite journal |author=Brodsky G, Barnes T, Bleskan J, ''et al.'' |title=The human GARS-AIRS-GART gene encodes two proteins which are differentially expressed during human brain development and temporally overexpressed in cerebellum of individuals with Down syndrome. |journal=Hum. Mol. Genet. |volume=6 |issue= 12 |pages= 2043–50 |year= 1997 |pmid= 9328467 |doi= 10.1093/hmg/6.12.2043}} |
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*{{cite journal |author=Kan JL, Moran RG |title=Intronic polyadenylation in the human glycinamide ribonucleotide formyltransferase gene. |journal=Nucleic Acids Res. |volume=25 |issue= 15 |pages= 3118–23 |year= 1997 |pmid= 9224613 |doi= 10.1093/nar/25.15.3118 |pmc=146841}} |
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*{{cite journal |author=Gomez HL, Santillana SL, Vallejos CS, ''et al.'' |title=A phase II trial of pemetrexed in advanced breast cancer: clinical response and association with molecular target expression. |journal=Clin. Cancer Res. |volume=12 |issue= 3 Pt 1 |pages= 832–8 |year= 2006 |pmid= 16467096 |doi= 10.1158/1078-0432.CCR-05-0295 }} |
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*{{cite journal |author=Zhang Y, Desharnais J, Greasley SE, ''et al.'' |title=Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR. |journal=Biochemistry |volume=41 |issue= 48 |pages= 14206–15 |year= 2002 |pmid= 12450384 |doi= 10.1021/bi020522m}} |
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*{{cite journal |author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928}} |
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*{{cite journal |author=Manieri W, Moore ME, Soellner MB, ''et al.'' |title=Human glycinamide ribonucleotide transformylase: active site mutants as mechanistic probes. |journal=Biochemistry |volume=46 |issue= 1 |pages= 156–63 |year= 2007 |pmid= 17198385 |doi= 10.1021/bi0619270 }} |
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*{{cite journal |author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241}} |
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*{{cite journal |author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }} |
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*{{cite journal |author=Zalkin H, Dixon JE |title=De novo purine nucleotide biosynthesis. |journal=Prog. Nucleic Acid Res. Mol. Biol. |volume=42 |issue= |pages= 259–87 |year= 1992 |pmid= 1574589 |doi= }} |
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*{{cite journal |author=Vieira AR, McHenry TG, Daack-Hirsch S, ''et al.'' |title=Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. |journal=Genet. Med. |volume=10 |issue= 9 |pages= 668–74 |year= 2008 |pmid= 18978678 |doi= 10.1097/GIM.0b013e3181833793 |pmc=2734954}} |
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*{{cite journal |author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 |pmc=1847948}} |
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*{{cite journal |author=Banerjee D, Nandagopal K |title=Phylogenetic analysis and in silico characterization of the GARS-AIRS-GART gene which codes for a tri-functional enzyme protein involved in de novo purine biosynthesis. |journal=Mol. Biotechnol. |volume=42 |issue= 3 |pages= 306–19 |year= 2009 |pmid= 19301155 |doi= 10.1007/s12033-009-9160-1 }} |
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{{refend}} |
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[[Категорија:ЕЦ 2.1.2]] |
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[[de:Trifunktionelles Purinsyntheseprotein]] |
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Верзија на датум 23. фебруар 2013. у 09:18
Trifunkcioni purinski biosintetički protein adenozin-3 je enzim koji je kod ljudi kodiran GART genom.[1]
Ovaj protein je trofunkcionalni polipeptid. On deluje kao fosforibozilglicinamid formiltransferaza (EC 6.3.4.13), fosforibozilglicinamidna sintetaza (EC 6.3.3.1), fosforibozilaminoimidazolna sintetaza (EC 2.1.2.2), koji je neophodan za de novo purinsku biosintezu.
Reference
Literatura
- Hattori M, Fujiyama A, Taylor TD; et al. (2000). „The DNA sequence of human chromosome 21.”. Nature. 405 (6784): 311—9. PMID 10830953. doi:10.1038/35012518.
- Banerjee D, Nandagopal K (2007). „Potential interaction between the GARS-AIRS-GART Gene and CP2/LBP-1c/LSF transcription factor in Down syndrome-related Alzheimer disease.”. Cell. Mol. Neurobiol. 27 (8): 1117—26. PMID 17902044. doi:10.1007/s10571-007-9217-2.
- Dahms TE, Sainz G, Giroux EL; et al. (2005). „The apo and ternary complex structures of a chemotherapeutic target: human glycinamide ribonucleotide transformylase.”. Biochemistry. 44 (29): 9841—50. PMID 16026156. doi:10.1021/bi050307g.
- Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). „Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.”. Genome Res. 16 (1): 55—65. PMC 1356129
. PMID 16344560. doi:10.1101/gr.4039406. - Dagle JM, Lepp NT, Cooper ME; et al. (2009). „Determination of genetic predisposition to patent ductus arteriosus in preterm infants.”. Pediatrics. 123 (4): 1116—23. PMC 2734952 . PMID 19336370. doi:10.1542/peds.2008-0313.
- Franke B, Vermeulen SH, Steegers-Theunissen RP; et al. (2009). „An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).”. Birth Defects Res. Part A Clin. Mol. Teratol. 85 (3): 216—26. PMID 19161160. doi:10.1002/bdra.20556.
- Barbe L, Lundberg E, Oksvold P; et al. (2008). „Toward a confocal subcellular atlas of the human proteome.”. Mol. Cell Proteomics. 7 (3): 499—508. PMID 18029348. doi:10.1074/mcp.M700325-MCP200.
- Zhang Y, Desharnais J, Marsilje TH; et al. (2003). „Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid.”. Biochemistry. 42 (20): 6043—56. PMID 12755606. doi:10.1021/bi034219c.
- Brodsky G, Barnes T, Bleskan J; et al. (1997). „The human GARS-AIRS-GART gene encodes two proteins which are differentially expressed during human brain development and temporally overexpressed in cerebellum of individuals with Down syndrome.”. Hum. Mol. Genet. 6 (12): 2043—50. PMID 9328467. doi:10.1093/hmg/6.12.2043.
- Kan JL, Moran RG (1997). „Intronic polyadenylation in the human glycinamide ribonucleotide formyltransferase gene.”. Nucleic Acids Res. 25 (15): 3118—23. PMC 146841 . PMID 9224613. doi:10.1093/nar/25.15.3118.
- Gomez HL, Santillana SL, Vallejos CS; et al. (2006). „A phase II trial of pemetrexed in advanced breast cancer: clinical response and association with molecular target expression.”. Clin. Cancer Res. 12 (3 Pt 1): 832—8. PMID 16467096. doi:10.1158/1078-0432.CCR-05-0295.
- Zhang Y, Desharnais J, Greasley SE; et al. (2002). „Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR.”. Biochemistry. 41 (48): 14206—15. PMID 12450384. doi:10.1021/bi020522m.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Manieri W, Moore ME, Soellner MB; et al. (2007). „Human glycinamide ribonucleotide transformylase: active site mutants as mechanistic probes.”. Biochemistry. 46 (1): 156—63. PMID 17198385. doi:10.1021/bi0619270.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2002). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Rush J, Moritz A, Lee KA; et al. (2005). „Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.”. Nat. Biotechnol. 23 (1): 94—101. PMID 15592455. doi:10.1038/nbt1046.
- Zalkin H, Dixon JE (1992). „De novo purine nucleotide biosynthesis.”. Prog. Nucleic Acid Res. Mol. Biol. 42: 259—87. PMID 1574589.
- Vieira AR, McHenry TG, Daack-Hirsch S; et al. (2008). „Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts.”. Genet. Med. 10 (9): 668—74. PMC 2734954 . PMID 18978678. doi:10.1097/GIM.0b013e3181833793.
- Ewing RM, Chu P, Elisma F; et al. (2007). „Large-scale mapping of human protein-protein interactions by mass spectrometry.”. Mol. Syst. Biol. 3 (1): 89. PMC 1847948 . PMID 17353931. doi:10.1038/msb4100134.
- Banerjee D, Nandagopal K (2009). „Phylogenetic analysis and in silico characterization of the GARS-AIRS-GART gene which codes for a tri-functional enzyme protein involved in de novo purine biosynthesis.”. Mol. Biotechnol. 42 (3): 306—19. PMID 19301155. doi:10.1007/s12033-009-9160-1.
Spoljašnje veze
- Phosphoribosylglycinamide+formyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
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