A-ribazolna fosfataza
(преусмерено са A-ribazol fosfataza)
| A-ribazolna fosfataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.3.73 | ||||||||
| CAS broj | 251991-06-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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A-ribazolna fosfataza (EC 3.1.3.73, CobC, adenozilkobalaminska fosfataza, alfa-ribazolna fosfataza) je enzim sa sistematskim imenom adenozilkobalamin/alfa-ribazol-5'-fosfat fosfohidrolaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) adenozilkobalamin 5'-fosfat + H2O koenzim B12 + fosfat
- (2) alfa-ribazole 5'-fosfat + H2O alfa-ribazole + fosfat
Ovaj enzim katalizuje zadnji korak anaerobne biosinteze adenozilkobalamina.
Reference[уреди | уреди извор]
- ^ O'Toole, G.A., Trzebiatowski, J.R. and Escalante-Semerena, J.C. (1994). „The cobC gene of Salmonella typhimurium codes for a novel phosphatase involved in the assembly of the nucleotide loop of cobalamin”. J. Biol. Chem. 269: 26503—26511. PMID 7929373.
- ^ Warren, M.J., Raux, E., Schubert, H.L. and Escalante-Semerena, J.C. (2002). „The biosynthesis of adenosylcobalamin (vitamin B12)”. Nat. Prod. Rep. 19: 390—412. PMID 12195810.
- ^ Zayas, C.L. & Escalante-Semerena, J.C. (2007). „Reassessment of the late steps of coenzyme B12 synthesis in Salmonella enterica: evidence that dephosphorylation of adenosylcobalamin-5′-phosphate by the CobC phosphatase is the last step of the pathway”. J. Bacteriol. 189: 2210—2218. PMID 17209023.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Adenosylcobalamin/alpha-ribazole+phosphatase на US National Library of Medicine Medical Subject Headings (MeSH)
