Ciklični-guanilat-specifična fosfodiestaraza
(преусмерено са C-di-GMP fosfodiesteraza)
| Ciklični-guanilat-specifična fosfodiestaraza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.4.52 | ||||||||
| CAS broj | 338732-46-0 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Ciklični-guanilat-specifična fosfodiestaraza (EC 3.1.4.52, ciklična bis(3->5')diguanilatna fosfodiesteraza, c-di-GMP-specifična fosfodiesteraza, c-di-GMP fosfodiesteraza, fosfodiesteraza, fosfodiesteraza A1, PDEA1, VieA) je enzim sa sistematskim imenom ciklična bis(3->5')diguanilat 3-guanililhidrolaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- ciklična di-3',5'-guanilat + H2O 5'-fosfoguanilil(3'->5')guanozin
Za dejstvo ovog enzima su neophodni Mg2+ ili Mn2+. Njega inhibiraju joni Ca2+ i Zn2+.
Reference[уреди | уреди извор]
- ^ Chang, A.L., Tuckerman, J.R., Gonzalez, G., Mayer, R., Weinhouse, H., Volman, G., Amikam, D., Benziman, M. and Gilles-Gonzalez, M.A. (2001). „Phosphodiesterase A1, a regulator of cellulose synthesis in Acetobacter xylinum, is a heme-based sensor”. Biochemistry. 40: 3420—3426. PMID 11297407.
- ^ Christen, M., Christen, B., Folcher, M., Schauerte, A. and Jenal, U. (2005). „Identification and characterization of a cyclic di-GMP-specific phosphodiesterase and its allosteric control by GTP”. J. Biol. Chem. 280: 30829—30837. PMID 15994307.
- ^ Schmidt, A.J., Ryjenkov, D.A. and Gomelsky, M. (2005). „The ubiquitous protein domain EAL is a cyclic diguanylate-specific phosphodiesterase: enzymatically active and inactive EAL domains”. J. Bacteriol. 187: 4774—4781. PMID 15995192.
- ^ Tamayo, R., Tischler, A.D. and Camilli, A. (2005). „The EAL domain protein VieA is a cyclic diguanylate phosphodiesterase”. J. Biol. Chem. 280: 33324—33330. PMID 16081414.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Cyclic-guanylate-specific+phosphodiesterase на US National Library of Medicine Medical Subject Headings (MeSH)
