N-acilneuraminat-9-fosfat sintaza
(преусмерено са EC 2.5.1.57)
| N-acilneuraminat-9-fosfat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.57 | ||||||||
| CAS broj | 9031-58-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
N-acilneuraminat-9-fosfat sintaza (EC 2.5.1.57, N-acetilneuraminat 9-fosfat lijaza, N-acetilneuraminat 9-fosfat sijalinska kiselina 9-fosfatna sintaza, N-acetilneuraminat 9-fosfatna sintetaza, N-acilneuraminat-9-fosfat piruvat-lijaza (piruvatna fosforilacija), sijalinska kiselina 9-fosfatna sintetaza) je enzim sa sistematskim imenom fosfoenolpiruvat:N-acil-D-manozamin-6-fosfat 1-(2-karboksi-2-oksoetil)transferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- fosfoenolpiruvat + N-acil-D-manozamin 6-fosfat + H 2O N-acilneuraminat 9-fosfat + fosfat
Ovaj enzim deluje na N-glikoloil i N-acetil-derivate.
Reference[уреди | уреди извор]
- ^ Roseman, S., Jourdian, G.W., Watson, D. and Rood, R. (1961). „Enzymatic synthesis of sialic acid 9-phosphates”. Proc. Natl. Acad. Sci. USA. 47: 958—961. PMID 13743311.
- ^ Watson, D.R., Jourdian, G.W. and Roseman, S. (1966). „The sialic acids. 8. Sialic acid 9-phosphate synthetase”. J. Biol. Chem. 241: 5627—5636. PMID 5928202.
- ^ Nakata, D., Close, B.E., Colley, K.J., Matsuda, T. and Kitajima, K. (2000). „Molecular cloning and expression of the mouse N-acetylneuraminic acid 9-phosphate synthase which does not have deaminoneuraminic acid (KDN) 9-phosphate synthase activity”. Biochem. Biophys. Res. Commun. 273: 642—648. PMID 10873658.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- N-acylneuraminate-9-phosphate+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
