Striktozidinska sintaza
| Striktozidinska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.3.3.2 | ||||||||
| CAS broj | 69669-72-3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Striktozidinska sintaza (EC 4.3.3.2, striktozidinska sintetaza, STR, 3-alfa(S)-strijtozidin triptamin-lijaza) je enzim sa sistematskim imenom 3-alfa(S)-striktozidin triptamin-lijaza (formira sekologanin).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 3-alfa(S)-striktozidin + H2O triptamin + sekologanin
Ovaj enzim katalizuje Piktet-Spenglerovu reakciju između aldehidne grupe sekologanina i amino grupe of triptamina.
Reference[уреди | уреди извор]
- ^ Treimer, J.K. & Zenk, M.H. (1979). „Purification and properties of strictosidine synthase, the key enzyme in indole alkaloid formation”. Eur. J. Biochem. 101: 225—233. PMID 510306.
- ^ Kutchan, T.M. (1993). „Strictosidine: from alkaloid to enzyme to gene”. Phytochemistry. 32: 493—506. PMID 7763429.
- ^ de Waal, A., Meijer, A.H. and Verpoorte, R. (1995). „Strictosidine synthase from Catharanthus roseus: purification and characterization of multiple forms”. Biochem. J. 306: 571—580. PMID 7887913.
- ^ Ruppert, M., Woll, J., Giritch, A., Genady, E., Ma, X. and Stöckigt, J. (2005). „Functional expression of an ajmaline pathway-specific esterase from Rauvolfia in a novel plant-virus expression system”. Planta. 222: 888—898. PMID 16133216.
- ^ McCoy, E., Galan, M.C. and O'Connor, S.E. (2006). „Substrate specificity of strictosidine synthase”. Bioorg. Med. Chem. Lett. 16: 2475—2478. PMID 16481164.
- ^ Ma, X., Panjikar, S., Koepke, J., Loris, E. and Stöckigt, J. (2006). „The structure of Rauvolfia serpentina strictosidine synthase is a novel six-bladed β-propeller fold in plant proteins”. Plant Cell. 18: 907—920. PMID 16531499.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Strictosidine+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
