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Demencije Levijevih tela su two similar and common subtypes of dementia:[1] Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD).[2][3][4][5] Both are characterized by changes in thinking, movement, behavior, and mood.[1] The two conditions have similar features and may have similar causes, and are believed to belong on a spectrum of Lewy body disease[2] that includes Parkinson's disease.[5] As of 2014, they were more often misdiagnosed than any other common dementia.[6]

The exact cause is unknown, but involves widespread deposits of abnormal clumps of protein that form in neurons of the diseased brain. Known as Lewy bodies (discovered in 1912 by Frederic Lewy[7]) and Lewy neurites, these clumps affect both the central nervous system and the autonomic nervous system.[8] The fifth revision of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) gives Lewy body disease as the causative subtype of dementia with Lewy bodies, and Parkinson's disease as the causative subtype of Parkinson's disease dementia.[9] Dementia with Lewy bodies is marked by the presence of Lewy bodies primarily in the cortical regions, and Parkinson's disease dementia with Lewy bodies primarily in the subcortical basal ganglia.[10]

Reference

  1. ^ а б Walker Z, Possin KL, Boeve BF, Aarsland D (октобар 2015). „Lewy body dementias”. Lancet (Review). 386 (10004): 1683—97. PMC 5792067 Слободан приступ. PMID 26595642. doi:10.1016/S0140-6736(15)00462-6. 
  2. ^ а б Gomperts SN (април 2016). „Lewy Body Dementias: Dementia With Lewy Bodies and Parkinson Disease Dementia”. Continuum (Minneap Minn). 22 (2 Dementia): 435—63. PMC 5390937 Слободан приступ. PMID 27042903. doi:10.1212/CON.0000000000000309. 
  3. ^ Pezzoli S, Cagnin A, Bandmann O, Venneri A (јул 2017). „Structural and Functional Neuroimaging of Visual Hallucinations in Lewy Body Disease: A Systematic Literature Review”. Brain Sci. 7 (12): 84. PMC 5532597 Слободан приступ. PMID 28714891. doi:10.3390/brainsci7070084 Слободан приступ. 
  4. ^ Galasko D (мај 2017). „Lewy Body Disorders”. Neurol Clin. 35 (2): 325—38. PMC 5912679 Слободан приступ. PMID 28410662. doi:10.1016/j.ncl.2017.01.004. 
  5. ^ а б Kon T, Tomiyama M, Wakabayashi K (фебруар 2020). „Neuropathology of Lewy body disease: Clinicopathological crosstalk between typical and atypical cases”. Neuropathology. 40 (1): 30—39. PMID 31498507. S2CID 201983865. doi:10.1111/neup.12597 Слободан приступ. 
  6. ^ Taylor A, Yardley C (2014). „Advocacy, education, and the role of not-for-profit organizations in Lewy body dementias”. Alzheimers Res Ther (Review). 6 (5): 59. PMC 4468791 Слободан приступ. PMID 26082807. doi:10.1186/s13195-014-0059-0 Слободан приступ. 
  7. ^ „Lewy body dementia: Hope through research”. National Institute of Neurological Disorders and Stroke. US National Institutes of Health. 10. 1. 2020. Приступљено 18. 3. 2020. 
  8. ^ Lin YW, Truong D (април 2019). „Diffuse Lewy body disease”. J. Neurol. Sci. (Review). 399: 144—50. PMID 30807982. S2CID 72335064. doi:10.1016/j.jns.2019.02.021. 
  9. ^ Diagnostic and statistical manual of mental disorders : DSM-5 (5th изд.). Arlington, VA: American Psychiatric Association. 2013. стр. 603—604. ISBN 9780890425541. 
  10. ^ Diagnostic and statistical manual of mental disorders : DSM-5. (5th изд.). Arlington, VA: American Psychiatric Association. 2013. стр. 619. ISBN 9780890425541. 
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