GPR77 — разлика између измена

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==Literatura==
==Literatura==
{{reflist|2}}
{{reflist|2}}

==Dodatna literatura==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ohno M, Hirata T, Enomoto M, ''et al.'' |title=A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells. |journal=Mol. Immunol. |volume=37 |issue= 8 |pages= 407–12 |year= 2000 |pmid= 11090875 |doi=10.1016/S0161-5890(00)00067-5 }}
*{{cite journal | author=Cain SA, Monk PN |title=The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74). |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7165–9 |year= 2002 |pmid= 11773063 |doi= 10.1074/jbc.C100714200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Kalant D, Cain SA, Maslowska M, ''et al.'' |title=The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein. |journal=J. Biol. Chem. |volume=278 |issue= 13 |pages= 11123–9 |year= 2003 |pmid= 12540846 |doi= 10.1074/jbc.M206169200 }}
*{{cite journal | author=Otto M, Hawlisch H, Monk PN, ''et al.'' |title=C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism. |journal=J. Biol. Chem. |volume=279 |issue= 1 |pages= 142–51 |year= 2004 |pmid= 14570896 |doi= 10.1074/jbc.M310078200 }}
*{{cite journal | author=Huber-Lang M, Sarma JV, Rittirsch D, ''et al.'' |title=Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans. |journal=J. Immunol. |volume=174 |issue= 2 |pages= 1104–10 |year= 2005 |pmid= 15634936 |doi= }}
*{{cite journal | author=Kalant D, MacLaren R, Cui W, ''et al.'' |title=C5L2 is a functional receptor for acylation-stimulating protein. |journal=J. Biol. Chem. |volume=280 |issue= 25 |pages= 23936–44 |year= 2005 |pmid= 15833747 |doi= 10.1074/jbc.M406921200 }}
*{{cite journal | author=Johswich K, Martin M, Thalmann J, ''et al.'' |title=Ligand specificity of the anaphylatoxin C5L2 receptor and its regulation on myeloid and epithelial cell lines. |journal=J. Biol. Chem. |volume=281 |issue= 51 |pages= 39088–95 |year= 2007 |pmid= 17068344 |doi= 10.1074/jbc.M609734200 }}
*{{cite journal | author=Scola AM, Higginbottom A, Partridge LJ, ''et al.'' |title=The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand binding. |journal=J. Biol. Chem. |volume=282 |issue= 6 |pages= 3664–71 |year= 2007 |pmid= 17158873 |doi= 10.1074/jbc.M609178200 | pmc=2873560 }}
}}
{{refend}}

Верзија на датум 8. април 2011. у 17:24

G protein-spregnuti receptor 77
Identifikatori
Simboli GPR77; C5L2; GPF77
Vanjski ID OMIM: 609949 MGI: 2442013 HomoloGene: 49549 IUPHAR: C5L2 GeneCards: GPR77 Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 27202 319430
Ensembl ENSG00000134830 ENSMUSG00000074361
UniProt Q9P296 n/a
RefSeq (mRNA) NM_018485 NM_176912
RefSeq (protein) NP_060955 NP_795886
Lokacija (UCSC) Chr 19:
52.54 - 52.54 Mb		 Chr 7:
15.4 - 15.4 Mb
PubMed pretraga [1] [2]

GPR77, G protein-spregnuti receptor 77, ili C5a anafilatoksinski hemotaksni receptor C5L2, je protein koji je kod čoveka kodiran GPR77 genom.[1][2]

Anafilatoksini C3a, C4a, i C5a su katjonski fragmenti formirani tokom kaskade komplementa koja učestvuje u odbrani domaćina. U slučaju neodgovarajuće aktivacije komplementa, anafilatoksini mogu da učestvuju u autoimunosti i sepsi. C5L2 je izražen zajedno sa C5a receptorom (C5R1), na polimorfonuklearnim neutrofilima i može da modulira C5AR aktivnost.[3][2]

Literatura

  1. ^ Lee DK, George SR, Cheng R, Nguyen T, Liu Y, Brown M, Lynch KR, O'Dowd BF (2001). „Identification of four novel human G protein-coupled receptors expressed in the brain”. Brain Res Mol Brain Res. 86 (1-2): 13—22. PMID 11165367. doi:10.1016/S0169-328X(00)00242-4.  Непознати параметар |month= игнорисан (помоћ)
  2. ^ а б „Entrez Gene: GPR77 G protein-coupled receptor 77”. 
  3. ^ Gerhard DS, Wagner L, Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 Слободан приступ. PMID 15489334. doi:10.1101/gr.2596504. 

Dodatna literatura

  • Ohno M, Hirata T, Enomoto M; et al. (2000). „A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells.”. Mol. Immunol. 37 (8): 407—12. PMID 11090875. doi:10.1016/S0161-5890(00)00067-5. 
  • Cain SA, Monk PN (2002). „The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74).”. J. Biol. Chem. 277 (9): 7165—9. PMID 11773063. doi:10.1074/jbc.C100714200. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 Слободан приступ. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Kalant D, Cain SA, Maslowska M; et al. (2003). „The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein.”. J. Biol. Chem. 278 (13): 11123—9. PMID 12540846. doi:10.1074/jbc.M206169200. 
  • Otto M, Hawlisch H, Monk PN; et al. (2004). „C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism.”. J. Biol. Chem. 279 (1): 142—51. PMID 14570896. doi:10.1074/jbc.M310078200. 
  • Huber-Lang M, Sarma JV, Rittirsch D; et al. (2005). „Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans.”. J. Immunol. 174 (2): 1104—10. PMID 15634936. 
  • Kalant D, MacLaren R, Cui W; et al. (2005). „C5L2 is a functional receptor for acylation-stimulating protein.”. J. Biol. Chem. 280 (25): 23936—44. PMID 15833747. doi:10.1074/jbc.M406921200. 
  • Johswich K, Martin M, Thalmann J; et al. (2007). „Ligand specificity of the anaphylatoxin C5L2 receptor and its regulation on myeloid and epithelial cell lines.”. J. Biol. Chem. 281 (51): 39088—95. PMID 17068344. doi:10.1074/jbc.M609734200. 
  • Scola AM, Higginbottom A, Partridge LJ; et al. (2007). „The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand binding.”. J. Biol. Chem. 282 (6): 3664—71. PMC 2873560 Слободан приступ. PMID 17158873. doi:10.1074/jbc.M609178200. 
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