Пређи на садржај

Ubikvitin C — разлика између измена

С Википедије, слободне енциклопедије
Интерактиван преглед историје
Новија измена →
Садржај обрисан Садржај додат
ВизуелноВикитекст
м Нова страница: {{PBB|geneid=7316}} '''Ubikvitin ''' je protein koji je kod čoveka kodiran {{Gene|UBC}} genom.<ref name="pmid1315303">{{Cite journal| author = Board PG, Coggan M,...
 
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==Interakcije==
Za ubikvitin C je pokazano da [[Protein-protein interakcija|interaguje]] sa -{[[SCNN1A]]}-,<ref name=pmid18632802>{{Cite journal |unused_data=pmid = 18667480 |last=Boulkroun |first=Sheerazed |authorlink= |coauthors=Ruffieux-Daidié Dorothée, Vitagliano Jean-Jacques, Poirot Olivier, Charles Roch-Philippe, Lagnaz Dagmara, Firsov Dmitri, Kellenberger Stephan, Staub Olivier |year=[[2008]]|month=Oct. |title=Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3 |journal=Am. J. Physiol. Renal Physiol. |volume=295 |issue=4 |pages=F889–900 |publisher= |location = United States| issn = 0363-6127| pmid = 18632802 |doi = 10.1152/ajprenal.00001.2008 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid18322022>{{Cite journal|last=Raikwar |first=Nandita S |authorlink= |coauthors=Thomas Christie P |year=[[2008]]|month=May. |title=Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel |journal=Am. J. Physiol. Renal Physiol. |volume=294 |issue=5 |pages=F1157–65 |publisher= |location = United States| issn = 0363-6127| pmid = 18322022 |doi = 10.1152/ajprenal.00339.2007 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=2424110 }}</ref> -{[[SCNN1G]]}-,<ref name=pmid18632802/><ref name=pmid18322022/> [[Parkin (ligaza)|Parkin (ligazom)]],<ref name=pmid18541373>{{Cite journal|last=Yu |first=Furong |authorlink= |coauthors=Zhou Jianhua |year=[[2008]]|month=Jul. |title=Parkin is ubiquitinated by Nrdp1 and abrogates Nrdp1-induced oxidative stress |journal=Neurosci. Lett. |volume=440 |issue=1 |pages=4–8 |publisher= |location = Ireland| issn = 0304-3940| pmid = 18541373 |doi = 10.1016/j.neulet.2008.05.052 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid18195004>{{Cite journal|last=Kawahara |first=Kohichi |authorlink= |coauthors=Hashimoto Makoto, Bar-On Pazit, Ho Gilbert J, Crews Leslie, Mizuno Hideya, Rockenstein Edward, Imam Syed Z, Masliah Eliezer |year=[[2008]]|month=Mar. |title=alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease |journal=J. Biol. Chem. |volume=283 |issue=11 |pages=6979–87 |publisher= |location = United States| issn = 0021-9258| pmid = 18195004 |doi = 10.1074/jbc.M710418200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[P70-S6 kinaza 1|-{P70-S6}- kinazom 1]],<ref name=pmid18279656>{{Cite journal|last=Panasyuk |first=Ganna |authorlink= |coauthors=Nemazanyy Ivan, Filonenko Valeriy, Gout Ivan |year=[[2008]]|month=May. |title=Ribosomal protein S6 kinase 1 interacts with and is ubiquitinated by ubiquitin ligase ROC1 |journal=Biochem. Biophys. Res. Commun. |volume=369 |issue=2 |pages=339–43 |publisher= |location = United States| issn = | pmid = 18279656 |doi = 10.1016/j.bbrc.2008.02.016 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> -{[[TRAF6]]}-,<ref name=pmid18724939>{{Cite journal|last=Newton |first=Kim |authorlink= |coauthors=Matsumoto Marissa L, Wertz Ingrid E, Kirkpatrick Donald S, Lill Jennie R, Tan Jenille, Dugger Debra, Gordon Nathaniel, Sidhu Sachdev S, Fellouse Frederic A, Komuves Laszlo, French Dorothy M, Ferrando Ronald E, Lam Cynthia, Compaan Deanne, Yu Christine, Bosanac Ivan, Hymowitz Sarah G, Kelley Robert F, Dixit Vishva M |year=[[2008]]|month=Aug. |title=Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies |journal=Cell |volume=134 |issue=4 |pages=668–78 |publisher= |location = United States| issn = | pmid = 18724939 |doi = 10.1016/j.cell.2008.07.039 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid18634786>{{Cite journal|last=Chen |first=Lu |authorlink= |coauthors=Dong Wei, Zou Tingting, Ouyang Lu, He Guoqing, Liu Yingle, Qi Yipeng |year=[[2008]]|month=Aug. |title=Protein phosphatase 4 negatively regulates LPS cascade by inhibiting ubiquitination of TRAF6 |journal=FEBS Lett. |volume=582 |issue=19 |pages=2843–9 |publisher= |location = Netherlands| issn = 0014-5793| pmid = 18634786 |doi = 10.1016/j.febslet.2008.07.014 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid18617513>{{Cite journal|last=Lamothe |first=Betty |authorlink= |coauthors=Campos Alejandro D, Webster William K, Gopinathan Ambily, Hur Lana, Darnay Bryant G |year=[[2008]]|month=Sep. |title=The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKL |journal=J. Biol. Chem. |volume=283 |issue=36 |pages=24871–80 |publisher= |location = United States| issn = 0021-9258| pmid = 18617513 |doi = 10.1074/jbc.M802749200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=2529010 }}</ref><ref name=pmid18347055>{{Cite journal|last=Conze |first=Dietrich B |authorlink= |coauthors=Wu Chuan-Jin, Thomas James A, Landstrom Allison, Ashwell Jonathan D |year=[[2008]]|month=May. |title=Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation |journal=Mol. Cell. 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Signal. |volume=20 |issue=6 |pages=1044–51 |publisher= |location = England| issn = 0898-6568| pmid = 18299187 |doi = 10.1016/j.cellsig.2008.01.015 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> -{[[HDAC3]]}-,<ref name=pmid18655026>{{Cite journal|last=Tan |first=Fengwei |authorlink= |coauthors=Lu Lifang, Cai Yun, Wang Jinglan, Xie Yunfei, Wang Lin, Gong Yanhua, Xu Bing-E, Wu Jun, Luo Ying, Qiang Boqin, Yuan Jiangang, Sun Xiaoqing, Peng Xiaozhong |year=[[2008]]|month=Jul. |title=Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells |journal=Proteomics |volume=8 |issue=14 |pages=2885–96 |publisher= |location = Germany| issn = | pmid = 18655026 |doi = 10.1002/pmic.200700887 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> -{[[SFPQ]]}-,<ref name=pmid16169070>{{Cite journal |unused_data=pmid = 16179252 |last=Stelzl |first=Ulrich |authorlink= |coauthors=Worm Uwe, Lalowski Maciej, Haenig Christian, Brembeck Felix H, Goehler Heike, Stroedicke Martin, Zenkner Martina, Schoenherr Anke, Koeppen Susanne, Timm Jan, Mintzlaff Sascha, Abraham Claudia, Bock Nicole, Kietzmann Silvia, Goedde Astrid, Toksöz Engin, Droege Anja, Krobitsch Sylvia, Korn Bernhard, Birchmeier Walter, Lehrach Hans, Wanker Erich E |year=[[2005]]|month=Sep. |title=A human protein-protein interaction network: a resource for annotating the proteome |journal=Cell |volume=122 |issue=6 |pages=957–68 |publisher= |location = United States| issn = 0092-8674| pmid = 16169070 |doi = 10.1016/j.cell.2005.08.029 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> -{[[S100A10]]}-,<ref name=pmid18434302>{{Cite journal|last=He |first=Kai-Li |authorlink= |coauthors=Deora Arunkumar B, Xiong Huabao, Ling Qi, Weksler Babette B, Niesvizky Ruben, Hajjar Katherine A |year=[[2008]]|month=Jul. |title=Endothelial cell annexin A2 regulates polyubiquitination and degradation of its binding partner S100A10/p11 |journal=J. 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U.S.A. |volume=105 |issue=36 |pages=13568–73 |publisher= |location = United States| issn = | pmid = 18757741 |doi = 10.1073/pnas.0806268105 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=2533230 }}</ref><ref name=pmid18358244>{{Cite journal|last=Patel |first=Rachana |authorlink= |coauthors=Maru Girish |year=[[2008]]|month=Jun. |title=Polymeric black tea polyphenols induce phase II enzymes via Nrf2 in mouse liver and lungs |journal=Free Radic. Biol. 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==Literatura==
==Literatura==

Верзија на датум 17. мај 2011. у 16:12

Ubikvitin C
PDB prikaz baziran na 1aar​.
Dostupne strukture
1aar​, 1cmx​, 1d3z​, 1f9j​, 1fxt​, 1g6j​, 1gjz​, 1nbf​, 1ogw​, 1otr​, 1p3q​, 1q0w​, 1q5w​, 1s1q​, 1sif​, 1tbe​, 1ubi​, 1ubq​, 1ud7​, 1uzx​, 1v80​, 1v81​, 1wr1​, 1wr6​, 1wrd​, 1xd3​, 1xqq​, 1yd8​, 1yiw​, 1yj1​, 1yx5​, 1yx6​, 1zgu​, 2ayo​, 2bgf​, 2c7m​, 2c7n​, 2d3g​, 2den​, 2dx5​, 2fcm​, 2fcn​, 2fcq​, 2fcs​, 2fid​, 2fif​, 2fuh​, 2g3q​, 2g45​, 2gbj​, 2gbk​, 2gbm​, 2gbn​, 2gbr​, 2gmi​, 2hd5​, 2hth​, 2ibi​, 2j7q​, 2nr2​, 2o6v​, 2oob​
Identifikatori
Simboli UBC; HMG20
Vanjski ID OMIM: 191340 MGI: 98889 HomoloGene: 39626 GeneCards: UBC Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 7316 22190
Ensembl ENSG00000150991 ENSMUSG00000008348
UniProt P0CG48 Q3TH47
RefSeq (mRNA) XM_001132949 XM_001001910
RefSeq (protein) XP_001132949 XP_001001910
Lokacija (UCSC) Chr 12:
123.96 - 123.97 Mb		 Chr 5:
125.68 - 125.68 Mb
PubMed pretraga [1] [2]

Ubikvitin je protein koji je kod čoveka kodiran UBC genom.[1][2][3]


Interakcije

Za ubikvitin C je pokazano da interaguje sa SCNN1A,[4][5] SCNN1G,[4][5] Parkin (ligazom),[6][7] P70-S6 kinazom 1,[8] TRAF6,[9][10][11][12][13] HDAC3,[14] SFPQ,[15] S100A10,[16] SMAD3,[17][18] NOTCH1,[19] HIF1A,[20][21][22] receptorom epidermalnog faktora rasta,[23][24][25] E2F1,[26] Basigin,[27] IRAK1,[9][12][28][29] NFE2L2,[30][31] RIPK1,[9][13][32][33][34] Mdm2,[35][36][37] Kapa opioidnim receptorom,[38] NUAK1,[39] BIRC2,[33][40][41] tiroidnim hormonskim receptorom alfa,[14] Sp1 transkriptnim faktorom,[42] SMURF2,[43][44] MARK4,[39] Cdk1,[14] PCNA[45][46][47] i P53.[23][35][36][37][48][49][50][51]

Literatura

  1. ^ Board PG, Coggan M, Baker RT, Vuust J, Webb GC (1992). „Localization of the human UBC polyubiquitin gene to chromosome band 12q24.3”. Genomics. 12 (4): 639—42. PMID 1315303. doi:10.1016/0888-7543(92)90287-3.  Непознати параметар |month= игнорисан (помоћ)
  2. ^ Marinovic AC, Zheng B, Mitch WE, Price SR (2002). „Ubiquitin (UbC) expression in muscle cells is increased by glucocorticoids through a mechanism involving Sp1 and MEK1”. J Biol Chem. 277 (19): 16673—81. PMID 11872750. doi:10.1074/jbc.M200501200.  Непознати параметар |month= игнорисан (помоћ)
  3. ^ „Entrez Gene: UBC ubiquitin C”. 
  4. ^ а б Boulkroun, Sheerazed (2008). „Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3”. Am. J. Physiol. Renal Physiol. United States. 295 (4): F889—900. ISSN 0363-6127. PMID 18632802. doi:10.1152/ajprenal.00001.2008.  Непознати параметар |month= игнорисан (помоћ); Непознати параметар |unused_data= игнорисан (помоћ); Непознати параметар |coauthors= игнорисан [|author= се препоручује] (помоћ); Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  5. ^ а б Raikwar, Nandita S (2008). „Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel”. Am. J. Physiol. Renal Physiol. United States. 294 (5): F1157—65. ISSN 0363-6127. PMC 2424110 Слободан приступ. PMID 18322022. doi:10.1152/ajprenal.00339.2007.  Непознати параметар |month= игнорисан (помоћ); Непознати параметар |coauthors= игнорисан [|author= се препоручује] (помоћ); Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  6. ^ Yu, Furong (2008). „Parkin is ubiquitinated by Nrdp1 and abrogates Nrdp1-induced oxidative stress”. Neurosci. Lett. Ireland. 440 (1): 4—8. ISSN 0304-3940. PMID 18541373. doi:10.1016/j.neulet.2008.05.052.  Непознати параметар |month= игнорисан (помоћ); Непознати параметар |coauthors= игнорисан [|author= се препоручује] (помоћ); Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  7. ^ Kawahara, Kohichi (2008). „alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease”. J. Biol. Chem. United States. 283 (11): 6979—87. ISSN 0021-9258. PMID 18195004. doi:10.1074/jbc.M710418200.  Непознати параметар |month= игнорисан (помоћ); Непознати параметар |coauthors= игнорисан [|author= се препоручује] (помоћ); Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  8. ^ Panasyuk, Ganna (2008). „Ribosomal protein S6 kinase 1 interacts with and is ubiquitinated by ubiquitin ligase ROC1”. Biochem. Biophys. Res. Commun. United States. 369 (2): 339—43. PMID 18279656. doi:10.1016/j.bbrc.2008.02.016.  Непознати параметар |month= игнорисан (помоћ); Непознати параметар |coauthors= игнорисан [|author= се препоручује] (помоћ); Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  9. ^ а б в Newton, Kim (2008). „Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies”. Cell. United States. 134 (4): 668—78. PMID 18724939. doi:10.1016/j.cell.2008.07.039.  Непознати параметар |month= игнорисан (помоћ); Непознати параметар |coauthors= игнорисан [|author= се препоручује] (помоћ); Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  10. ^ Chen, Lu (2008). „Protein phosphatase 4 negatively regulates LPS cascade by inhibiting ubiquitination of TRAF6”. FEBS Lett. Netherlands. 582 (19): 2843—9. ISSN 0014-5793. PMID 18634786. doi:10.1016/j.febslet.2008.07.014.  Непознати параметар |month= игнорисан (помоћ); Непознати параметар |coauthors= игнорисан [|author= се препоручује] (помоћ); Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  11. ^ Lamothe, Betty (2008). „The RING domain and first zinc finger of TRAF6 coordinate signaling by interleukin-1, lipopolysaccharide, and RANKL”. J. Biol. Chem. United States. 283 (36): 24871—80. ISSN 0021-9258. PMC 2529010 Слободан приступ. PMID 18617513. doi:10.1074/jbc.M802749200.  Непознати параметар |month= игнорисан (помоћ); Непознати параметар |coauthors= игнорисан [|author= се препоручује] (помоћ); Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  12. ^ а б Conze, Dietrich B (2008). „Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation”. Mol. Cell. Biol. United States. 28 (10): 3538—47. PMC 2423148 Слободан приступ. PMID 18347055. doi:10.1128/MCB.02098-07.  Непознати параметар |month= игнорисан (помоћ); Непознати параметар |coauthors= игнорисан [|author= се препоручује] (помоћ); Проверите вредност парамет(а)ра за датум: |date= (помоћ)
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  14. ^ а б в Tan, Fengwei (2008). „Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells”. Proteomics. Germany. 8 (14): 2885—96. PMID 18655026. doi:10.1002/pmic.200700887.  Непознати параметар |month= игнорисан (помоћ); Непознати параметар |coauthors= игнорисан [|author= се препоручује] (помоћ); Проверите вредност парамет(а)ра за датум: |date= (помоћ)
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  16. ^ He, Kai-Li (2008). „Endothelial cell annexin A2 regulates polyubiquitination and degradation of its binding partner S100A10/p11”. J. Biol. Chem. United States. 283 (28): 19192—200. ISSN 0021-9258. PMC 2443646 Слободан приступ. PMID 18434302. doi:10.1074/jbc.M800100200.  Непознати параметар |month= игнорисан (помоћ); Непознати параметар |coauthors= игнорисан [|author= се препоручује] (помоћ); Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  17. ^ Stolfi, Carmine (2008). „Mesalazine negatively regulates CDC25A protein expression and promotes accumulation of colon cancer cells in S phase”. Carcinogenesis. England. 29 (6): 1258—66. PMID 18495657. doi:10.1093/carcin/bgn122.  Непознати параметар |month= игнорисан (помоћ); Непознати параметар |coauthors= игнорисан [|author= се препоручује] (помоћ); Проверите вредност парамет(а)ра за датум: |date= (помоћ)
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