Adenozinski A2A receptor — разлика између измена

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Ovaj protein je član familije [[GPCR|G protein-spregnutih receptora]] koji imaju sedam transmembranskih [[alfa heliks|alfa heliksa]]. [[Kristalografija|Kristalografska]] struktura adenozinskog A<sub>2A</sub> receptora ({{PDB2|3EML}}) pokazuje da je mesto vezivanja [[ligand (biohemija)|liganda]] distinktno u odnosu na druge GPCR proteine sa određenom strukturom (npr., [[beta-2 adrenergički receptor]] i [[rodopsin]]).<ref name="pmid18832607">{{cite journal | author = Jaakola VP, Griffith MT, Hanson MA, Cherezov V, Chien EY, Lane JR, IJzerman AP, Stevens RC | title = The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist | journal = Science | volume = 322| issue = 5905| pages = 1211–7| year = 2008 | month = October | pmid = 18832607 | doi = 10.1126/science.1164772 | url = | pmc = 2586971 }}</ref>
Ovaj protein je član familije [[GPCR|G protein-spregnutih receptora]] koji imaju sedam transmembranskih [[alfa heliks|alfa heliksa]]. [[Kristalografija|Kristalografska]] struktura adenozinskog A<sub>2A</sub> receptora ({{PDB2|3EML}}) pokazuje da je mesto vezivanja [[ligand (biohemija)|liganda]] distinktno u odnosu na druge GPCR proteine sa određenom strukturom (npr., [[beta-2 adrenergički receptor]] i [[rodopsin]]).<ref name="pmid18832607">{{cite journal | author = Jaakola VP, Griffith MT, Hanson MA, Cherezov V, Chien EY, Lane JR, IJzerman AP, Stevens RC | title = The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist | journal = Science | volume = 322| issue = 5905| pages = 1211–7| year = 2008 | month = October | pmid = 18832607 | doi = 10.1126/science.1164772 | url = | pmc = 2586971 }}</ref>


===Heteromeri===
Dejstva A<sub>2A</sub> receptora su komplikovana činjenicom da je mnoštvo funkcionalnih [[heteromer]]a, koji su kombinacije A<sub>2A</sub> podjedinica i drugih nesrodnih G-protein spregnutih receptora, nađeno u mozgu. To uvećava kompleksnost uloge adenozina u modulaciji neuronske aktivnosti. Heteromeri koji sadrže adenozinski A<sub>1</sub>/A<sub>2A</sub>,<ref name="pmid16481441">{{cite journal | author = Ciruela F, Casadó V, Rodrigues RJ, Luján R, Burgueño J, Canals M, Borycz J, Rebola N, Goldberg SR, Mallol J, Cortés A, Canela EI, López-Giménez JF, Milligan G, Lluis C, Cunha RA, Ferré S, Franco R | title = Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers | journal = The Journal of Neuroscience : the Official Journal of the Society for Neuroscience | volume = 26 | issue = 7 | pages = 2080–7 | year = 2006 | month = February | pmid = 16481441 | doi = 10.1523/JNEUROSCI.3574-05.2006 | url = | issn = }}</ref><ref name="pmid17981720">{{cite journal | author = Ferre S, Ciruela F, Borycz J, Solinas M, Quarta D, Antoniou K, Quiroz C, Justinova Z, Lluis C, Franco R, Goldberg SR | title = Adenosine A1-A2A receptor heteromers: new targets for caffeine in the brain | journal = Frontiers in Bioscience : a Journal and Virtual Library | volume = 13 | issue = 13| pages = 2391–9 | year = 2008 | pmid = 17981720 | doi = 10.2741/2852| url = http://www.bioscience.org/2008/v13/af/2852/fulltext.htm | issn = }}</ref> dopaminski [[dopaminski receptor D2|-{D<sub>2</sub>}-]]/A<sub>2A</sub><ref name="pmid16012194">{{cite journal | author = Fuxe K, Ferré S, Canals M, Torvinen M, Terasmaa A, Marcellino D, Goldberg SR, Staines W, Jacobsen KX, Lluis C, Woods AS, Agnati LF, Franco R | title = Adenosine A2A and dopamine D2 heteromeric receptor complexes and their function | journal = Journal of Molecular Neuroscience : MN | volume = 26 | issue = 2-3 | pages = 209–20 | year = 2005 | pmid = 16012194 | doi = 10.1385/JMN:26:2-3:209 | url = | issn = }}</ref> i[[dopaminski receptor D3|-{D}-<sub>3</sub>]]/A<sub>2A</sub>,<ref name="pmid15539641">{{cite journal | author = Torvinen M, Marcellino D, Canals M, Agnati LF, Lluis C, Franco R, Fuxe K | title = Adenosine A2A receptor and dopamine D3 receptor interactions: evidence of functional A2A/D3 heteromeric complexes | journal = Molecular Pharmacology | volume = 67 | issue = 2 | pages = 400–7 | year = 2005 | month = February | pmid = 15539641 | doi = 10.1124/mol.104.003376 | url = | issn = }}</ref> glutamatni [[Metabotropni glutamatni receptor 5|-{mGluR}-<sub>5</sub>]]/A<sub>2A</sub><ref name="pmid18246094">{{cite journal | author = Zezula J, Freissmuth M | title = The A(2A)-adenosine receptor: a GPCR with unique features? | journal = British Journal of Pharmacology | volume = Suppl 1 | issue = S1| pages = S184–90 | year = 2008 | series = 153 | month = March | pmid = 18246094 | pmc = 2268059 | doi = 10.1038/sj.bjp.0707674 | url = | issn = }}</ref> i kanabinoidni [[kanabinoidni receptor 1|-{CB}-<sub>1</sub>]]/A<sub>2A</sub><ref name="pmid18691604">{{cite journal | author = Ferré S, Goldberg SR, Lluis C, Franco R | title = Looking for the role of cannabinoid receptor heteromers in striatal function | journal = Neuropharmacology | volume = Suppl 1 | issue = | pages = 226–34 | series = 56 | year = 2009 | pmid = 18691604 | doi = 10.1016/j.neuropharm.2008.06.076 | url = | issn = | pmc = 2635338 }}</ref> su zapaženi, kao i -{CB<sub>1</sub>/A<sub>2A</sub>/D<sub>2</sub>}- [[Heterotrimerni G protein|heterotrimeri]].<ref name="pmid18262573">{{cite journal | author = Marcellino D, Carriba P, Filip M, Borgkvist A, Frankowska M, Bellido I, Tanganelli S, Müller CE, Fisone G, Lluis C, Agnati LF, Franco R, Fuxe K | title = Antagonistic cannabinoid CB1/dopamine D2 receptor interactions in striatal CB1/D2 heteromers. A combined neurochemical and behavioral analysis | journal = Neuropharmacology | volume = 54 | issue = 5 | pages = 815–23 | year = 2008 | month = April | pmid = 18262573 | doi = 10.1016/j.neuropharm.2007.12.011 | url = | issn = }}</ref> Istraživanje funkcionalnog značaja i [[endogen]]e uloge tih hibridnih receptora je u toku.<ref name="pmid17982579">{{cite journal | author = Ferré S, Ciruela F, Quiroz C, Luján R, Popoli P, Cunha RA, Agnati LF, Fuxe K, Woods AS, Lluis C, Franco R | title = Adenosine receptor heteromers and their integrative role in striatal function | journal = TheScientificWorldJournal | volume = 7 | issue = | pages = 74–85 | year = 2007 | pmid = 17982579 | doi = 10.1100/tsw.2007.211 | url = | issn = | doi_brokendate = 2010-08-02 }}</ref><ref name="pmid18508501">{{cite journal | author = Wardas J | title = Potential role of adenosine A2A receptors in the treatment of schizophrenia | journal = Frontiers in Bioscience : a Journal and Virtual Library | volume = 13 | issue = 13| pages = 4071–96 | year = 2008 | pmid = 18508501 | doi = 10.2741/2995| url = http://www.bioscience.org/2008/v13/af/2995/fulltext.htm | issn = }}</ref><ref name="pmid18537671">{{cite journal | author = Simola N, Morelli M, Pinna A | title = Adenosine A2A receptor antagonists and Parkinson's disease: state of the art and future directions | journal = Current Pharmaceutical Design | volume = 14 | issue = 15 | pages = 1475–89 | year = 2008 | pmid = 18537671 | doi = 10.2174/138161208784480072| url = | issn = }}</ref>
== Literatura ==
== Literatura ==
{{reflist|2}}
{{reflist|2}}

Верзија на датум 29. јун 2011. у 06:24

Adenozinski A2A receptor
Kristalografska struktura adenozinskog A2A receptora (N-terminus = plavo, C-terminus = crveno) u kompleksu sa ZM-241,385 (štapićasti dijagram), bazirana na 3EML​ koordinatama.
Dostupne strukture
3EML​
Identifikatori
Simboli ADORA2A; ADORA2; RDC8; hA2AR
Vanjski ID OMIM: 102776 MGI: 99402 HomoloGene: 20166 IUPHAR: A2A GeneCards: ADORA2A Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 135 11540
Ensembl ENSG00000128271 ENSMUSG00000020178
UniProt P29274 Q2NLC1
RefSeq (mRNA) NM_000675 NM_009630
RefSeq (protein) NP_000666 NP_033760
Lokacija (UCSC) Chr 22:
23.15 - 23.17 Mb		 Chr 10:
74.77 - 74.78 Mb
PubMed pretraga [1] [2]

Adenozinski A2A receptor (ADORA2A) je adenozinski receptor. On je kodiran humanim ADORA2A genom.[1][2]

Struktura

Ovaj protein je član familije G protein-spregnutih receptora koji imaju sedam transmembranskih alfa heliksa. Kristalografska struktura adenozinskog A2A receptora (3EML​) pokazuje da je mesto vezivanja liganda distinktno u odnosu na druge GPCR proteine sa određenom strukturom (npr., beta-2 adrenergički receptor i rodopsin).[3]

Heteromeri

Dejstva A2A receptora su komplikovana činjenicom da je mnoštvo funkcionalnih heteromera, koji su kombinacije A2A podjedinica i drugih nesrodnih G-protein spregnutih receptora, nađeno u mozgu. To uvećava kompleksnost uloge adenozina u modulaciji neuronske aktivnosti. Heteromeri koji sadrže adenozinski A1/A2A,[4][5] dopaminski D2/A2A[6] iD3/A2A,[7] glutamatni mGluR5/A2A[8] i kanabinoidni CB1/A2A[9] su zapaženi, kao i CB1/A2A/D2 heterotrimeri.[10] Istraživanje funkcionalnog značaja i endogene uloge tih hibridnih receptora je u toku.[11][12][13]

Literatura

  1. ^ Libert F, Parmentier M, Lefort A, Dinsart C, Van Sande J, Maenhaut C, Simons MJ, Dumont JE, Vassart G (1989). „Selective amplification and cloning of four new members of the G protein-coupled receptor family”. Science. 244 (4904): 569—72. PMID 2541503. doi:10.1126/science.2541503.  Непознати параметар |month= игнорисан (помоћ)
  2. ^ Libert F, Passage E, Parmentier M, Simons MJ, Vassart G, Mattei MG (1991). „Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor”. Genomics. 11 (1): 225—7. PMID 1662665. doi:10.1016/0888-7543(91)90125-X.  Непознати параметар |month= игнорисан (помоћ)
  3. ^ Jaakola VP, Griffith MT, Hanson MA, Cherezov V, Chien EY, Lane JR, IJzerman AP, Stevens RC (2008). „The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist”. Science. 322 (5905): 1211—7. PMC 2586971 Слободан приступ. PMID 18832607. doi:10.1126/science.1164772.  Непознати параметар |month= игнорисан (помоћ)
  4. ^ Ciruela F, Casadó V, Rodrigues RJ, Luján R, Burgueño J, Canals M, Borycz J, Rebola N, Goldberg SR, Mallol J, Cortés A, Canela EI, López-Giménez JF, Milligan G, Lluis C, Cunha RA, Ferré S, Franco R (2006). „Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers”. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 26 (7): 2080—7. PMID 16481441. doi:10.1523/JNEUROSCI.3574-05.2006.  Непознати параметар |month= игнорисан (помоћ)
  5. ^ Ferre S, Ciruela F, Borycz J, Solinas M, Quarta D, Antoniou K, Quiroz C, Justinova Z, Lluis C, Franco R, Goldberg SR (2008). „Adenosine A1-A2A receptor heteromers: new targets for caffeine in the brain”. Frontiers in Bioscience : a Journal and Virtual Library. 13 (13): 2391—9. PMID 17981720. doi:10.2741/2852. 
  6. ^ Fuxe K, Ferré S, Canals M, Torvinen M, Terasmaa A, Marcellino D, Goldberg SR, Staines W, Jacobsen KX, Lluis C, Woods AS, Agnati LF, Franco R (2005). „Adenosine A2A and dopamine D2 heteromeric receptor complexes and their function”. Journal of Molecular Neuroscience : MN. 26 (2-3): 209—20. PMID 16012194. doi:10.1385/JMN:26:2-3:209. 
  7. ^ Torvinen M, Marcellino D, Canals M, Agnati LF, Lluis C, Franco R, Fuxe K (2005). „Adenosine A2A receptor and dopamine D3 receptor interactions: evidence of functional A2A/D3 heteromeric complexes”. Molecular Pharmacology. 67 (2): 400—7. PMID 15539641. doi:10.1124/mol.104.003376.  Непознати параметар |month= игнорисан (помоћ)
  8. ^ Zezula J, Freissmuth M (2008). „The A(2A)-adenosine receptor: a GPCR with unique features?”. British Journal of Pharmacology. 153. Suppl 1 (S1): S184—90. PMC 2268059 Слободан приступ. PMID 18246094. doi:10.1038/sj.bjp.0707674.  Непознати параметар |month= игнорисан (помоћ)
  9. ^ Ferré S, Goldberg SR, Lluis C, Franco R (2009). „Looking for the role of cannabinoid receptor heteromers in striatal function”. Neuropharmacology. 56. Suppl 1: 226—34. PMC 2635338 Слободан приступ. PMID 18691604. doi:10.1016/j.neuropharm.2008.06.076. 
  10. ^ Marcellino D, Carriba P, Filip M, Borgkvist A, Frankowska M, Bellido I, Tanganelli S, Müller CE, Fisone G, Lluis C, Agnati LF, Franco R, Fuxe K (2008). „Antagonistic cannabinoid CB1/dopamine D2 receptor interactions in striatal CB1/D2 heteromers. A combined neurochemical and behavioral analysis”. Neuropharmacology. 54 (5): 815—23. PMID 18262573. doi:10.1016/j.neuropharm.2007.12.011.  Непознати параметар |month= игнорисан (помоћ)
  11. ^ Ferré S, Ciruela F, Quiroz C, Luján R, Popoli P, Cunha RA, Agnati LF, Fuxe K, Woods AS, Lluis C, Franco R (2007). „Adenosine receptor heteromers and their integrative role in striatal function”. TheScientificWorldJournal. 7: 74—85. PMID 17982579. doi:10.1100/tsw.2007.211 (неактивно 2010-08-02). 
  12. ^ Wardas J (2008). „Potential role of adenosine A2A receptors in the treatment of schizophrenia”. Frontiers in Bioscience : a Journal and Virtual Library. 13 (13): 4071—96. PMID 18508501. doi:10.2741/2995. 
  13. ^ Simola N, Morelli M, Pinna A (2008). „Adenosine A2A receptor antagonists and Parkinson's disease: state of the art and future directions”. Current Pharmaceutical Design. 14 (15): 1475—89. PMID 18537671. doi:10.2174/138161208784480072. 
Преузето из „https://sr.wikipedia.org/w/index.php?title=Adenozinski_A2A_receptor&oldid=4506203”