Kanabinoidni receptor 2 — разлика између измена

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== Reference ==
== Reference ==
{{reflist|2}}
{{reflist|2}}

== Literatura ==
{{Refbegin | 2}}
{{PBB_Further reading
| citations =
*{{cite journal | author=Oddi S, Spagnuolo P, Bari M, ''et al.'' |title=Differential modulation of type 1 and type 2 cannabinoid receptors along the neuroimmune axis |journal=Int. Rev. Neurobiol. |volume=82 |pages= 327–37 |year= 2007 |pmid= 17678969 |doi= 10.1016/S0074-7742(07)82017-4 | chapter=Differential Modulation of Type 1 and Type 2 Cannabinoid Receptors along the Neuroimmune Axis | series=International Review of Neurobiology | isbn=978-0-12-373989-6 }}
*{{cite journal | author=Galiègue S, Mary S, Marchand J, ''et al.'' |title=Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations |journal=Eur. J. Biochem. |volume=232 |issue= 1 |pages= 54–61 |year= 1995 |pmid= 7556170 |doi=10.1111/j.1432-1033.1995.tb20780.x }}
*{{cite journal | author=Munro S, Thomas KL, Abu-Shaar M |title=Molecular characterization of a peripheral receptor for cannabinoids |journal=Nature |volume=365 |issue= 6441 |pages= 61–5 |year= 1993 |pmid= 7689702 |doi= 10.1038/365061a0 }}
*{{cite journal | author=Shire D, Calandra B, Rinaldi-Carmona M, ''et al.'' |title=Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor |journal=Biochim. Biophys. Acta |volume=1307 |issue= 2 |pages= 132–6 |year= 1996 |pmid= 8679694 |doi=10.1016/0167-4781(96)00047-4}}
*{{cite journal | author=Tao Q, McAllister SD, Andreassi J, ''et al.'' |title=Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2): evidence for subtype specificity |journal=Mol. Pharmacol. |volume=55 |issue= 3 |pages= 605–13 |year= 1999 |pmid= 10051546 }}
*{{cite journal | author=Nong L, Newton C, Friedman H, Klein TW |title=CB1 and CB2 receptor mRNA expression in human peripheral blood mononuclear cells (PBMC) from various donor types |journal=Adv. Exp. Med. Biol. |volume=493 |pages= 229–33 |year= 2002 |pmid= 11727770 |doi=10.1007/0-306-47611-8_27 | chapter=CB1 and CB2 Receptor mRNA Expression in Human Peripheral Blood Mononuclear Cells (PBMC) from Various Donor Types | series=Advances in Experimental Medicine and Biology | isbn=0-306-46466-7 }}
*{{cite journal | author=Ho BY, Current L, Drewett JG |title=Role of intracellular loops of cannabinoid CB(1) receptor in functional interaction with G(alpha16) |journal=FEBS Lett. |volume=522 |issue= 1–3 |pages= 130–4 |year= 2002 |pmid= 12095632 |doi=10.1016/S0014-5793(02)02917-4 }}
*{{cite journal | author=Matias I, Pochard P, Orlando P, ''et al.'' |title=Presence and regulation of the endocannabinoid system in human dendritic cells |journal=Eur. J. Biochem. |volume=269 |issue= 15 |pages= 3771–8 |year= 2002 |pmid= 12153574 |doi=10.1046/j.1432-1033.2002.03078.x }}
*{{cite journal | author=Song ZH, Feng W |title=Absence of a conserved proline and presence of a conserved tyrosine in the CB2 cannabinoid receptor are crucial for its function |journal=FEBS Lett. |volume=531 |issue= 2 |pages= 290–4 |year= 2002 |pmid= 12417328 |doi=10.1016/S0014-5793(02)03537-8 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Casanova ML, Blázquez C, Martínez-Palacio J, ''et al.'' |title=Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors |journal=J. Clin. Invest. |volume=111 |issue= 1 |pages= 43–50 |year= 2003 |pmid= 12511587 |doi=10.1172/JCI16116 | pmc=151833 }}
*{{cite journal | author=Feng W, Song ZH |title=Effects of D3.49A, R3.50A, and A6.34E mutations on ligand binding and activation of the cannabinoid-2 (CB2) receptor |journal=Biochem. Pharmacol. |volume=65 |issue= 7 |pages= 1077–85 |year= 2003 |pmid= 12663043 |doi=10.1016/S0006-2952(03)00005-4 }}
*{{cite journal | author=Kishimoto S, Gokoh M, Oka S, ''et al.'' |title=2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism |journal=J. Biol. Chem. |volume=278 |issue= 27 |pages= 24469–75 |year= 2003 |pmid= 12711605 |doi= 10.1074/jbc.M301359200 }}
*{{cite journal | author=Jorda MA, Rayman N, Valk P, ''et al.'' |title=Identification, characterization, and function of a novel oncogene: the peripheral cannabinoid receptor Cb2 |journal=Ann. N. Y. Acad. Sci. |volume=996 |pages= 10–6 |year= 2003 |pmid= 12799277 | doi = 10.1111/j.1749-6632.2003.tb03227.x }}
*{{cite journal | author=Rayman N, Lam KH, Laman JD, ''et al.'' |title=Distinct expression profiles of the peripheral cannabinoid receptor in lymphoid tissues depending on receptor activation status |journal=J. Immunol. |volume=172 |issue= 4 |pages= 2111–7 |year= 2004 |pmid= 14764676 }}
*{{cite journal | author=Rao GK, Zhang W, Kaminski NE |title=Cannabinoid receptor-mediated regulation of intracellular calcium by delta(9)-tetrahydrocannabinol in resting T cells |journal=J. Leukoc. Biol. |volume=75 |issue= 5 |pages= 884–92 |year= 2004 |pmid= 14966196 |doi= 10.1189/jlb.1203638 }}
*{{cite journal | author=Alberich Jordà M, Rayman N, Tas M, ''et al.'' |title=The peripheral cannabinoid receptor Cb2, frequently expressed on AML blasts, either induces a neutrophilic differentiation block or confers abnormal migration properties in a ligand-dependent manner |journal=Blood |volume=104 |issue= 2 |pages= 526–34 |year= 2004 |pmid= 15039279 |doi= 10.1182/blood-2003-12-4357 }}
*{{cite journal | author=Núñez E, Benito C, Pazos MR, ''et al.'' |title=Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical study |journal=Synapse |volume=53 |issue= 4 |pages= 208–13 |year= 2004 |pmid= 15266552 |doi= 10.1002/syn.20050 }}
*{{cite journal | author=Gokoh M, Kishimoto S, Oka S, ''et al.'' |title=2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces rapid actin polymerization in HL-60 cells differentiated into macrophage-like cells |journal=Biochem. J. |volume=386 |issue= Pt 3 |pages= 583–9 |year= 2005 |pmid= 15456404 |doi= 10.1042/BJ20041163 | pmc=1134878 }}
}}
*{{cite doi|10.1038/sj.bjp.0707523}}
{{Refend}}


==Spoljašnje veze==
==Spoljašnje veze==

Верзија на датум 27. јул 2012. у 05:04

Kanabinoidni receptor 2 (makrofag)
Prikaz baziran na PDB 2KI9​.
Dostupne strukture
2KI9​
Identifikatori
Simboli CNR2; CB-2; CB2; CX5
Vanjski ID OMIM: 605051 MGI: 104650 HomoloGene: 1389 IUPHAR: CB2 GeneCards: CNR2 Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 1269 12802
Ensembl ENSG00000188822 ENSMUSG00000062585
UniProt P34972 P47936
RefSeq (mRNA) NM_001841.2 NM_009924.3
RefSeq (protein) NP_001832.1 NP_034054.3
Lokacija (UCSC) Chr 1:
24.2 - 24.29 Mb		 Chr 4:
135.45 - 135.48 Mb
PubMed pretraga [1] [2]

Kanabinoidni receptor tip 2 (CB2) je G protein spregnuti receptor iz familije kanabinoidnih receptora koja je kod ljudi kodirana CNR2 genom.[1][2] On je blisko srodan sa kanabinoidnim receptorom tip 1, koji je u znatnoj meri odgovoran za efikasnost endokanabinoidno posredovane presinaptičke inhibicije, psihoaktivnih svojstava tetrahidrokanabinola, aktivnog agenta marihuane, i drugih fitokanabinoida.[1][3] Glavni endogeni ligand za CB2 receptor je 2-arahidonoilglicerol (2-AG).[2]

CB2 je bio kloniran 1993. od strane istraživačke grupe iz Kembridža koja je tragala za drugim kanabinoidnim receptorom koji bi mogla da objasni farmakološke osobine tetrahidrokanabinola.[1] Receptor je identifikovan među cDNA molekulima na bazi sličnosti njegove aminokiselinske sekvence sa kanabinoidnim receptorskim tipom 1 (CB1) receptora, otkrivenim 1990.[4] Otkriće ovog receptora je pomoglo u pružanju molekulskog objašnjenja za uspostavljanje dejstva kanabinoida u imunskom sistemu.

Reference

  1. ^ а б в Munro S, Thomas KL, Abu-Shaar M (1993). „Molecular characterization of a peripheral receptor for cannabinoids”. Nature. 365 (6441): 61—5. PMID 7689702. doi:10.1038/365061a0.  Непознати параметар |month= игнорисан (помоћ)
  2. ^ а б PMID 22048769 (PMID 22048769)
    Референца ће бити завршена аутоматски за неколико минута. Прескочи ред или прошири ручно
  3. ^ „Entrez Gene: CNR2 cannabinoid receptor 2 (macrophage)”. 
  4. ^ PMID 11316486 (PMID 11316486)
    Референца ће бити завршена аутоматски за неколико минута. Прескочи ред или прошири ручно

Literatura

  • Oddi S, Spagnuolo P, Bari M; et al. (2007). „Differential modulation of type 1 and type 2 cannabinoid receptors along the neuroimmune axis”. Int. Rev. Neurobiol. International Review of Neurobiology. 82: 327—37. ISBN 978-0-12-373989-6. PMID 17678969. doi:10.1016/S0074-7742(07)82017-4.  |chapter= игнорисан (помоћ)
  • Galiègue S, Mary S, Marchand J; et al. (1995). „Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations”. Eur. J. Biochem. 232 (1): 54—61. PMID 7556170. doi:10.1111/j.1432-1033.1995.tb20780.x. 
  • Munro S, Thomas KL, Abu-Shaar M (1993). „Molecular characterization of a peripheral receptor for cannabinoids”. Nature. 365 (6441): 61—5. PMID 7689702. doi:10.1038/365061a0. 
  • Shire D, Calandra B, Rinaldi-Carmona M; et al. (1996). „Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor”. Biochim. Biophys. Acta. 1307 (2): 132—6. PMID 8679694. doi:10.1016/0167-4781(96)00047-4. 
  • Tao Q, McAllister SD, Andreassi J; et al. (1999). „Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2): evidence for subtype specificity”. Mol. Pharmacol. 55 (3): 605—13. PMID 10051546. 
  • Nong L, Newton C, Friedman H, Klein TW (2002). „CB1 and CB2 receptor mRNA expression in human peripheral blood mononuclear cells (PBMC) from various donor types”. Adv. Exp. Med. Biol. Advances in Experimental Medicine and Biology. 493: 229—33. ISBN 0-306-46466-7. PMID 11727770. doi:10.1007/0-306-47611-8_27.  |chapter= игнорисан (помоћ)
  • Ho BY, Current L, Drewett JG (2002). „Role of intracellular loops of cannabinoid CB(1) receptor in functional interaction with G(alpha16)”. FEBS Lett. 522 (1–3): 130—4. PMID 12095632. doi:10.1016/S0014-5793(02)02917-4. 
  • Matias I, Pochard P, Orlando P; et al. (2002). „Presence and regulation of the endocannabinoid system in human dendritic cells”. Eur. J. Biochem. 269 (15): 3771—8. PMID 12153574. doi:10.1046/j.1432-1033.2002.03078.x. 
  • Song ZH, Feng W (2002). „Absence of a conserved proline and presence of a conserved tyrosine in the CB2 cannabinoid receptor are crucial for its function”. FEBS Lett. 531 (2): 290—4. PMID 12417328. doi:10.1016/S0014-5793(02)03537-8. 
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 Слободан приступ. PMID 12477932. doi:10.1073/pnas.242603899. 
  • Casanova ML, Blázquez C, Martínez-Palacio J; et al. (2003). „Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors”. J. Clin. Invest. 111 (1): 43—50. PMC 151833 Слободан приступ. PMID 12511587. doi:10.1172/JCI16116. 
  • Feng W, Song ZH (2003). „Effects of D3.49A, R3.50A, and A6.34E mutations on ligand binding and activation of the cannabinoid-2 (CB2) receptor”. Biochem. Pharmacol. 65 (7): 1077—85. PMID 12663043. doi:10.1016/S0006-2952(03)00005-4. 
  • Kishimoto S, Gokoh M, Oka S; et al. (2003). „2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism”. J. Biol. Chem. 278 (27): 24469—75. PMID 12711605. doi:10.1074/jbc.M301359200. 
  • Jorda MA, Rayman N, Valk P; et al. (2003). „Identification, characterization, and function of a novel oncogene: the peripheral cannabinoid receptor Cb2”. Ann. N. Y. Acad. Sci. 996: 10—6. PMID 12799277. doi:10.1111/j.1749-6632.2003.tb03227.x. 
  • Rayman N, Lam KH, Laman JD; et al. (2004). „Distinct expression profiles of the peripheral cannabinoid receptor in lymphoid tissues depending on receptor activation status”. J. Immunol. 172 (4): 2111—7. PMID 14764676. 
  • Rao GK, Zhang W, Kaminski NE (2004). „Cannabinoid receptor-mediated regulation of intracellular calcium by delta(9)-tetrahydrocannabinol in resting T cells”. J. Leukoc. Biol. 75 (5): 884—92. PMID 14966196. doi:10.1189/jlb.1203638. 
  • Alberich Jordà M, Rayman N, Tas M; et al. (2004). „The peripheral cannabinoid receptor Cb2, frequently expressed on AML blasts, either induces a neutrophilic differentiation block or confers abnormal migration properties in a ligand-dependent manner”. Blood. 104 (2): 526—34. PMID 15039279. doi:10.1182/blood-2003-12-4357. 
  • Núñez E, Benito C, Pazos MR; et al. (2004). „Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical study”. Synapse. 53 (4): 208—13. PMID 15266552. doi:10.1002/syn.20050. 
  • Gokoh M, Kishimoto S, Oka S; et al. (2005). „2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces rapid actin polymerization in HL-60 cells differentiated into macrophage-like cells”. Biochem. J. 386 (Pt 3): 583—9. PMC 1134878 Слободан приступ. PMID 15456404. doi:10.1042/BJ20041163. 
  • Пажња: Шаблон ({{cite doi}}) је застарео. Да би навели публикацију која се идентификује са doi:10.1038/sj.bjp.0707523, користите шаблон {{cite journal}} (ако је објављен у bona fide академском часопису, у другом случају користите шаблон {{cite report}} са |doi=10.1038/sj.bjp.0707523).

Spoljašnje veze

Преузето из „https://sr.wikipedia.org/w/index.php?title=Kanabinoidni_receptor_2&oldid=5769780”