11-cis-retinol dehidrogenaza
| 11-cis-retinol dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.315 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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11-Cis-retinol dehidrogenaza (EC 1.1.1.315, RDH5 (gen)) je enzim sa sistematskim imenom 11-cis-retinol:NAD+ oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 11-cis-retinol---[retinal-vezujući-protein] + NAD+ 11-cis-retinal---[retinol-vezujući-protein] + NADH + H+
Ovaj enzim, izobilno prisutan u retinalnom pigmentnom epitelijumu, katalizuje redukciju 11-cis-retinola do 11-cis-retinala, dok je supstrat vezan za retinal-vezujući protein. To je presudni korak u regeneraciji 11-cis-retinala, hromofora rodopsina. Ovaj enzim takođe može da deluje na druge cis forme retinola.
Reference[уреди | уреди извор]
- ^ Simon, A., Hellman, U., Wernstedt, C. and Eriksson, U. (1995). „The retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases”. J. Biol. Chem. 270: 1107—1112. PMID 7836368.
- ^ Wang, J., Chai, X., Eriksson, U. and Napoli, J.L. (1999). „Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue”. Biochem. J. 338: 23—27. PMID 9931293.
- ^ Liden, M., Romert, A., Tryggvason, K., Persson, B. and Eriksson, U. (2001). „Biochemical defects in 11-cis-retinol dehydrogenase mutants associated with fundus albipunctatus”. J. Biol. Chem. 276: 49251—49257. PMID 11675386.
- ^ Wu, Z., Yang, Y., Shaw, N., Bhattacharya, S., Yan, L., West, K., Roth, K., Noy, N., Qin, J. and Crabb, J.W. (2003). „Mapping the ligand binding pocket in the cellular retinaldehyde binding protein”. J. Biol. Chem. 278: 12390—12396. PMID 12536149.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- 11-cis-retinol+dehydrogenase на US National Library of Medicine Medical Subject Headings (MeSH)
