3-(3-hidroksifenil)propanoat hidroksilaza
| 3-(3-hidroksifenil)propanoat hidroksilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.127 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
3-(3-hidroksifenil)propanoat hidroksilaza (EC 1.14.13.127, mhpA (gen)) je enzim sa sistematskim imenom 3-(3-hidroksifenil)propanoat,NADH:kiseonik oksidoreduktaza (2-hidroksilacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) 3-(3-hidroksifenil)propanoat + NADH + H+ + O2 3-(2,3-dihidroksifenil)propanoat + H2O + NAD+
- (2) (2E)-3-(3-hidroksifenil)prop-2-enoat + NADH + H+ + O2 (2E)-3-(2,3-dihidroksifenil)prop-2-enoat + H2O + NAD+
Ovaj enzim je flavoprotein (FAD). On učestvuje u meta odvanju kod bakterije Escherichia coli pri degradaciji raznih fenilpropanoidnih jedinjenja.
Reference[уреди | уреди извор]
- ^ Burlingame, R. & Chapman, P.J. (1983). „Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli”. J. Bacteriol. 155: 113—121. PMID 6345502.
- ^ Burlingame, R.P., Wyman, L. and Chapman, P.J. (1986). „Isolation and characterization of Escherichia coli mutants defective for phenylpropionate degradation”. J. Bacteriol. 168: 55—64. PMID 3531186.
- ^ Ferrández, A., García, J.L. and Díaz, E. (1997). „Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12”. J. Bacteriol. 179: 2573—2581. PMID 9098055.
- ^ Díaz, E., Ferrández, A. and García, J.L. (1998). „Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12”. J. Bacteriol. 180: 2915—2923. PMID 9603882.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- 3-(3-hydroxyphenyl)propanoate+hydroxylase на US National Library of Medicine Medical Subject Headings (MeSH)
