Cistein sintaza
| Cistein sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.47 | ||||||||
| CAS broj | 37290-89-4 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Cistein sintaza (EC 2.5.1.47, O-acetil-L-serin sulfhidrilaza, O-acetil-L-serin sulfohidrolaza, O-acetilserin (tiol)-lijaza, O-acetilserin (tiol)-lijaza A, O-acetilserin sulfhidrilaza, O3-acetil-L-serin acetat-lijaza (dodaje vodonik-sulfid), acetilserin sulfhidrilaza, cistein sintetaza, S-sulfocistein sintaza, 3-O-acetil-L-serin:vodonik-sulfid 2-amino-2-karboksietiltransferaza) je enzim sa sistematskim imenom O3-acetil-L-serin:vodonik-sulfid 2-amino-2-karboksietiltransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- O3-acetil-L-serin + vodonik sulfid L-cistein + acetat
Ovaj enzim je piridoksal-fosfatni protein. Pojedini alkilni tioli, cijanidi, pirazoli i neka druga heterociklična jedinjenja mogu da deluju kao akceptori.
Reference[уреди | уреди извор]
- ^ Becker, M.A., Kredich, N.M. and Tomkins, G.M. (1969). „The purification and characterization of O-acetylserine sulfhydrylase-A from Salmonella typhimurium”. J. Biol. Chem. 244: 2418—2427. PMID 4891157.
- ^ Hara, S., Payne, M.A., Schnackerz, K.D. and Cook, P.F. (1990). „A rapid purification procedure and computer-assisted sulfide ion selective electrode assay for O-acetylserine sulfhydrylase from Salmonella typhimurium”. Protein Expr. Purif. 1: 70—76. PMID 2152186.
- ^ Ikegami, F., Kaneko, M., Lambein, F., Kuo, Y.-H. and Murakoshi, I. (1987). „Difference between uracilylalanine synthases and cysteine synthases in Pisum sativum”. Phytochemistry. 26: 2699—2704.
- ^ Murakoshi, I., Kaneko, M., Koide, C. and Ikegami, F. (1986). „Enzymatic-synthesis of the neuroexcitatory amino-acid quisqualic by cysteine synthase”. Phytochemistry. 25: 2759—2763.
- ^ Tai, C.H., Burkhard, P., Gani, D., Jenn, T., Johnson, C. and Cook, P.F. (2001). „Characterization of the allosteric anion-binding site of O-acetylserine sulfhydrylase”. Biochemistry. 40: 7446—7452. PMID 11412097.
- ^ Bettati, S., Benci, S., Campanini, B., Raboni, S., Chirico, G., Beretta, S., Schnackerz, K.D., Hazlett, T.L., Gratton, E. and Mozzarelli, A. (2000). „Role of pyridoxal 5′-phosphate in the structural stabilization of O-acetylserine sulfhydrylase”. J. Biol. Chem. 275: 40244—40251. PMID 10995767.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Cysteine+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
