DNK oksidativna demetilaza
| DNK oksidativna demetilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.11.33 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
DNK oksidativna demetilaza (EC 1.14.11.33, protein popravke alkilisane DNK, alfa-ketoglutarat-zavisna dioksigenaza ABH1, alkB (gen)) je enzim sa sistematskim imenom metil DNA-base, 2-oksoglutarat:kiseonik oksidoreduktaza (formira formaldehid).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- DNK-baza-CH3 + 2-oksoglutarat + O2 DNK-baza + formaldehid + sukcinat + CO2
Ovaj enzim sadrži gvožđe. Njegovo dejstvo u maloj meri stimuliše askorbat.
Reference[уреди | уреди извор]
- ^ Falnes, P.O., Johansen, R.F. and Seeberg, E. (2002). „AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli”. Nature. 419: 178—182. PMID 12226668.
- ^ Yi, C., Yang, C.G. and He, C. (2009). „A non-heme iron-mediated chemical demethylation in DNA and RNA”. Acc. Chem. Res. 42: 519—529. PMID 19852088.
- ^ Yi, C., Jia, G., Hou, G., Dai, Q., Zhang, W., Zheng, G., Jian, X., Yang, C.G., Cui, Q. and He, C. (2010). „Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase”. Nature. 468: 330—333. PMID 21068844.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- DNA+oxidative+demethylase на US National Library of Medicine Medical Subject Headings (MeSH)
