Ekdizon 20-monooksigenaza
| Ekdizon 20-monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.99.22 | ||||||||
| CAS broj | 55071-97-1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Ekdizon 20-monooksigenaza (EC 1.14.99.22, alfa-ekdizonska C-20 hidroksilaza, ekdizonska 20-hidroksilaza) je enzim sa sistematskim imenom ekdizon,vodonik-donor:kiseonik oksidoreduktaza (20-hidroksilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- ekdizon + AH2 + O2 20-hidroksiekdizon + A + H2O
Enzim iz telesne masti insekata je hem-tiolatni protein (P-450). NADPH može da deluje kao donor vodonika.
Reference[уреди | уреди извор]
- ^ Johnson, P. & Rees, H.H. (1977). „The mechanism of C-20 hydroxylation of α-ecdysone in the desert locust, Schistocerca gregaria”. Biochem. J. 168: 513—520. PMID 606249.
- ^ Nigg, H.N., Svoboda, J.A., Thompson, M.J., Dutky, S.R., Kaplanis, J.N. and Robbins, W.E. (1976). „Ecdysome 20-hydroxylase from the midgut of the tobacco hornworm (Manduca sexta L.)”. Experientia. 32: 438—439. PMID 5286.
- ^ Smith, S.L., Bollenbacher, W.E., Cooper, D.Y., Schleyer, H., Wielgus, J.J. and Gilbert, L.I. (1979). „Ecdysone 20-monooxygenase: characterization of an insect cytochrome p-450 dependent steroid hydroxylase”. Mol. Cell. Endocrinol. 15: 111—133. PMID 488526.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze[уреди | уреди извор]
- Ecdysone+20-monooxygenase на US National Library of Medicine Medical Subject Headings (MeSH)
